Division of Diabetology, Paolo Borsellino Hospital, Marsala, Italy.
Prim Care Diabetes. 2011 Dec;5(4):241-4. doi: 10.1016/j.pcd.2011.06.001. Epub 2011 Jun 24.
To assess the prevalence of Graves' disease in patients with type 1 diabetes mellitus all coming from a defined geographical area (western Sicily-Italy) and to investigate the clinical features of these subjects.
The records of 470 consecutive patients with type 1 diabetes mellitus referred in a 5-year period were analyzed.
During the period of the survey, out of 470 patients with type 1 diabetes, 14 (3%) had a previous diagnosis of Graves' disease. There were 9 female and 5 male; these patients showed a high age at diabetes onset (mean 38 years). Diagnosis of Graves' disease was often pre-existing or simultaneous to that of diabetes. Vitiligo was coexisting in 4 subjects; none of them presented other autoimmune diseases. Graves' orbitopathy was present in two cases.
Our data confirm the frequent association between Graves' disease and type 1 diabetes. Graves' disease often preceded diagnosis of type 1 diabetes, particularly in female subjects with a high age at diabetes onset; therefore, in these subjects, an active search for the presence of pancreatic autoimmunity is warranted for many years after thyroid dysfunction appearance.
评估来自特定地理区域（意大利西西里西部）的 1 型糖尿病患者中 Graves 病的患病率，并研究这些患者的临床特征。
分析了在 5 年内就诊的 470 例连续 1 型糖尿病患者的记录。
在调查期间，470 例 1 型糖尿病患者中有 14 例（3%）曾被诊断为 Graves 病。其中 9 例为女性，5 例为男性；这些患者的糖尿病发病年龄较高（平均 38 岁）。Graves 病的诊断通常先于或同时于糖尿病诊断。4 例患者同时存在白癜风；他们均未患有其他自身免疫性疾病。2 例存在 Graves 眼病。
我们的数据证实 Graves 病与 1 型糖尿病之间存在频繁的关联。Graves 病通常先于 1 型糖尿病诊断，尤其是在糖尿病发病年龄较高的女性患者中；因此，在这些患者中，在甲状腺功能异常出现后多年，应积极寻找胰腺自身免疫的存在。
