Mascarenhas Andreia, Eusébio Marilene, Freitas Orquídea, Almeida Teresa
Department of General Pediatrics, Hospital Dona Estefânia, Rua Jacinta Marta, Lisboa, Portugal.
BMJ Case Rep. 2011 Feb 17;2011:bcr1220103618. doi: 10.1136/bcr.12.2010.3618.
Acquired factor X deficiency is an extremely rare situation. It has shown to be associated with systemic amyloidosis, respiratory mycoplasma infection, factor X inhibitors, antiphospholipid antibodies, vitamin K deficiency/liver disease as well as the use of certain medications (meropenem, valproic acid). The pathogenesis and transient nature of this deficit remain poorly understood. The authors describe the case of a teenager hospitalised for extensive burns that developed active bleeding after removal of central venous catheter. He was diagnosed with transient factor X deficiency. Normalisation of coagulation status and factor X levels occurred spontaneously 10 days after the bleeding episode.
获得性X因子缺乏是一种极为罕见的情况。已表明它与系统性淀粉样变性、呼吸道支原体感染、X因子抑制剂、抗磷脂抗体、维生素K缺乏/肝病以及某些药物（美罗培南、丙戊酸）的使用有关。这种缺乏的发病机制和短暂性仍知之甚少。作者描述了一名因大面积烧伤住院的青少年病例，该患者在拔除中心静脉导管后出现活动性出血。他被诊断为短暂性X因子缺乏。出血事件发生10天后，凝血状态和X因子水平自发恢复正常。
