Adnan Menderes University, Faculty of Medicine, Division of Hematology, Aydin, Turkey.
Mediterr J Hematol Infect Dis. 2012;4(1):e2012034. doi: 10.4084/MJHID.2012.034. Epub 2012 May 7.
A 28-year-old man from East Mediterranean area admitted with abdominal pain, weight loss and diarrhea. Barium x-ray studies showed segmentation, dilatation of bowel loops, mucosal folds thickening and delayed intestinal transit. Histological examination of biopsy specimens revealed villous atrophy and plasmacytic infiltration limited to mucosa and submucosa. Computed tomography showed multiple lymphadenopathy in the abdomen. Serum protein electropheresis and immunoelectropheresis indicated elevated IgA concentration. Bone marrow aspiration and biopsy revealed presence of lymphoplasmacytic infiltration. Immunohistochemical analysis of the intestine, lymph nodes showed positivity for CD45, CD-79, CD-20. After tetracycline treatment the patient's symptoms, abdominal lymphadenopathy and bone marrow infiltration disappeared and IgA concentration decreased to normal levels.
一位 28 岁的东地中海地区男性，因腹痛、体重减轻和腹泻入院。钡剂 X 射线研究显示肠段分割、肠袢扩张、黏膜皱襞增厚和肠传输延迟。活检标本的组织学检查显示绒毛萎缩和浆细胞浸润仅限于黏膜和黏膜下层。计算机断层扫描显示腹部有多处淋巴结病。血清蛋白电泳和免疫电泳显示 IgA 浓度升高。骨髓抽吸和活检显示存在淋巴浆细胞浸润。肠和淋巴结的免疫组织化学分析显示 CD45、CD-79、CD-20 阳性。四环素治疗后，患者的症状、腹部淋巴结病和骨髓浸润消失，IgA 浓度降至正常水平。
