Ter Arkh. 2012;84(3):45-8.
To study annual decline of pulmonary function in individuals exposed to chronic intermittent hypoxia (CIH) working in conditions of high altitude for 5 years.
A total of 9553 spirograms were obtained during 5 annual examinations of 795 open-cast miners (age 38.6 +/- 8.5 years, 6.4 +/- 5.0 years of service) working at the altitude of 3800-4500 m above the sea level. The miners were examined using spirometry with bronchodilation test.
An annual decline of vital lung capacity (VC) was 33.5 ml/year of forced VC - 33.8 ml/year, forced expiratory volume (FEV1)--64.4 ml/year. In the group of non-smokers the decline was less than in smokers--FEV1 59.5 ml/year vs 72.0 ml/year. No-smoking rules in the open-cast mine inhibited a respiratory function decline.
Individuals exposed to CIH show an accelerated decline of spirometric indices. No-smoking rules at open-cast high altitude mines result in inhibition of annual decline of respiratory function in CIH-exposed individuals including non-smokers. Smoking ban in such conditions not only inhibits decline of the respiratory function but improves this function.
研究在高海拔环境下工作5年且暴露于慢性间歇性缺氧（CIH）的个体肺功能的年度下降情况。
对海拔3800 - 4500米工作的795名露天矿工（年龄38.6±8.5岁，工龄6.4±5.0年）进行了5次年度检查，共获得9553份肺功能图。使用肺活量测定法并进行支气管扩张试验对矿工进行检查。
肺活量（VC）的年度下降为33.5毫升/年，用力肺活量为33.8毫升/年，用力呼气量（FEV1）为64.4毫升/年。在非吸烟组中，下降幅度小于吸烟组——FEV1分别为59.5毫升/年和72.0毫升/年。露天矿的禁烟规定抑制了呼吸功能的下降。
暴露于CIH的个体肺活量测定指标下降加速。露天高海拔矿的禁烟规定可抑制包括非吸烟者在内的暴露于CIH个体的呼吸功能年度下降。在这种情况下禁烟不仅能抑制呼吸功能下降，还能改善该功能。
