ICREC, Heart Failure and Cardiac Regeneration, Research Program, Health Sciences Research Institute Germans Trias i Pujol, Cardiology Service, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain.
Int J Cardiol. 2013 Jul 15;167(1):22-5. doi: 10.1016/j.ijcard.2012.05.082. Epub 2012 Jun 17.
The human heart has limited regenerative capacity. We focused on cardiac adipose tissue as a source of progenitor cells and biological matrix material for salvaging injured myocardium. First, a population of human adult mesenchymal-like progenitors derived from cardiac adipose tissue, with inherent cardiac and endothelial cell potential, was identified and characterized. Next, a salvage strategy was tested, where a pericardial-derived, vascularized, adipose flap was used to cover oxygen-deprived myocardium in a porcine model. The fat flap reduced the myocardial scar size, in both acute and chronic infarcts. A human clinical trial to examine this novel intervention is currently underway.
人类心脏的再生能力有限。我们专注于心房脂肪组织作为祖细胞的来源和用于抢救受损心肌的生物基质材料。首先，我们从心房脂肪组织中分离出具有固有心脏和内皮细胞潜能的人成体间充质样祖细胞，并对其进行了鉴定和特征分析。接下来，我们测试了一种抢救策略，即用心包衍生的、血管化的脂肪瓣覆盖猪模型中缺氧的心肌。脂肪瓣减少了急性和慢性梗死的心肌瘢痕大小。目前正在进行一项临床试验，以检验这种新的干预措施。
