Boehm G, Bierbach U, Senger H, Jakobsson I, Minoli I, Moro G, Räihä N
Department of Paediatrics, Karl-Marx University, Leipzig, GDR.
Biomed Biochim Acta. 1990;49(5):369-73.
In 17 very low birth weight and in 13 low birth weight infants appropriate for gestational age the activities of pancreatic lipase and trypsin, the pH value and the concentrations of total bile acids were measured in the preprandially aspirated duodenal juice between the 10th and the 40th day of postnatal life. The activities of both enzymes increased significantly with increasing postnatal age in both study groups but did not correlate with the gestational age between the 28th and 33rd week of gestation. The pH values were on a low but similar level in both study groups (mean for all infants 5.66 +/- 0.07), and there was no influence of the pH value on the activities of either pancreatic enzyme. The concentrations of total bile acids were also not different between the study groups (mean for all infants = 4.55 +/- 2.26 mmol/l) and no correlation could be found between the concentrations of total bile acids and the activities of both measured enzymes. The data suggest that the intrauterine development of the exocrine pancreas reaches a basal level by the 28th week of gestation and remains on this level up to the 33rd week of gestation. After birth there is a significant increase in enzyme activities for both studied enzymes.
在17名极低出生体重儿和13名适于胎龄的低出生体重儿中，于出生后第10天至第40天期间，测量了餐前抽取的十二指肠液中胰脂肪酶和胰蛋白酶的活性、pH值以及总胆汁酸浓度。在两个研究组中，两种酶的活性均随出生后年龄的增加而显著升高，但在孕28周和33周之间，与胎龄无相关性。两个研究组的pH值均较低但相似（所有婴儿的平均值为5.66±0.07），且pH值对任何一种胰酶的活性均无影响。两个研究组的总胆汁酸浓度也无差异（所有婴儿的平均值 = 4.55±2.26 mmol/L），且未发现总胆汁酸浓度与所测两种酶的活性之间存在相关性。数据表明，外分泌胰腺的宫内发育在孕28周时达到基础水平，并在孕33周前维持该水平。出生后，所研究的两种酶的活性均显著增加。
