Boehm G, Bierbach U, DelSanto A, Moro G, Minoli I
Center for Infant Nutrition to Prevent Illnesses in Adult Life, Milan, Italy.
Biol Neonate. 1995;67(4):248-53. doi: 10.1159/000244172.
Lipase and trypsin activities were estimated in preprandially aspirated duodenal juice of preterm infants with gestational ages between 29 and 32 weeks (group I, n = 33) or between 33 and 36 weeks (group II, n = 22) during the first 6 weeks of postnatal life. The results were compared with the enzyme activities measured in 2- to 6-year-old children. There were no significant differences of the mean lipase or trypsin activities between the two groups lipase; group I 13.7 +/- 7.9, group II 15.9 +/- 9.8 U/ml; trypsin: group I 7.9 +/- 4.7, group II 8.5 +/- 5.1 U/ml). The activities of both enzymes increased significantly and similarly in both groups with postnatal age (lipase: group I r = 0.732, p < 0.01, group II r = 0.743, p < 0.01; trypsin: group I r = 0.705, p < 0.01, group II r = 0.669, p < 0.01). At the end of the study the lipase activities of both groups reached approximately 35% of the values found in the older children, whereas the trypsin activities reached the reference values within the 1st month of life. The results indicate an asynchronously age-related development of lipase and trypsin. The development of the lipase activity is delayed in comparison to the trypsin activity which should be considered in the nutritional management of preterm infants.
在出生后前6周内，对胎龄在29至32周之间的早产儿（第一组，n = 33）和33至36周之间的早产儿（第二组，n = 22）餐前抽取的十二指肠液中的脂肪酶和胰蛋白酶活性进行了评估。将结果与2至6岁儿童测量的酶活性进行比较。两组之间的平均脂肪酶或胰蛋白酶活性没有显著差异（脂肪酶：第一组13.7±7.9，第二组15.9±9.8 U/ml；胰蛋白酶：第一组7.9±4.7，第二组8.5±5.1 U/ml）。随着出生后年龄的增长，两组中两种酶的活性均显著且相似地增加（脂肪酶：第一组r = 0.732，p < 0.01，第二组r = 0.743，p < 0.01；胰蛋白酶：第一组r = 0.705，p < 0.01，第二组r = 0.669，p < 0.01）。在研究结束时，两组的脂肪酶活性均达到大龄儿童所测值的约35%，而胰蛋白酶活性在出生后第1个月内达到参考值。结果表明脂肪酶和胰蛋白酶的发育与年龄不同步。与胰蛋白酶活性相比，脂肪酶活性的发育延迟，这在早产儿的营养管理中应予以考虑。
