Boehm G, Borte M, Müller H, Moro G, Minoli I
Center for infant nutrition, Milan.
Am J Clin Nutr. 1995 Mar;61(3):524-7. doi: 10.1093/ajcn/61.3.524.
The influence of three different feeding regimens on the activities of pancreatic lipase and trypsin in duodenal aspirates and on fecal nitrogen and fat excretion was studied in 35 healthy preterm infants after a 2-wk feeding period. Eleven infants received a standard preterm formula (without long-chain polyunsaturated fatty acids), 12 were fed with an experimental formula that only differed from the standard formula in fat blend composition (with long-chain polyunsaturated fatty acids), and 12 infants received human milk fortified with protein and energy to have similar nitrogen and energy contents as the two formulas. There were no significant differences in duodenal trypsin activities among the groups. In the group fed the standard formula, lipase activity was significantly lower than in the group fed the experimental formula (standard formula group: 8.4 +/- 3.5 kU/L; experimental formula group: 13.8 +/- 4.8 kU/L; P < 0.05) but there was no significant difference between the experimental formula group and the human milk group (15.1 +/- 4.2 kU/L). Fecal nitrogen as well as fat excretion were similar in the three feeding groups. The data suggest that dietary fat composition can influence the postnatal development of duodenal lipase activity in preterm infants.
在35名健康早产儿经过2周喂养期后，研究了三种不同喂养方案对十二指肠抽吸物中胰脂肪酶和胰蛋白酶活性以及粪便氮和脂肪排泄的影响。11名婴儿接受标准早产儿配方奶粉（不含长链多不饱和脂肪酸），12名婴儿喂养一种仅在脂肪混合成分上与标准配方奶粉不同的实验配方奶粉（含长链多不饱和脂肪酸），12名婴儿接受添加了蛋白质和能量以使其氮和能量含量与两种配方奶粉相似的强化母乳。各实验组之间十二指肠胰蛋白酶活性无显著差异。在喂养标准配方奶粉的组中，脂肪酶活性显著低于喂养实验配方奶粉的组（标准配方奶粉组：8.4±3.5 kU/L；实验配方奶粉组：13.8±4.8 kU/L；P<0.05），但实验配方奶粉组与母乳喂养组（15.1±4.2 kU/L）之间无显著差异。三个喂养组的粪便氮和脂肪排泄相似。数据表明，饮食脂肪组成可影响早产儿十二指肠脂肪酶活性的出生后发育。
