Division of Comprehensive Prosthodontics, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Apr;115(4):e12-9. doi: 10.1016/j.oooo.2011.10.028. Epub 2012 Jun 17.
Alveolar cancellous bone biopsy samples were extracted during dental implant preparation for investigating microstructural changes due to menopause and relationships between these changes and bone turnover markers.
Subjects were 18 women receiving mandibular implants: premenopausal (n = 5), early postmenopausal (≤5 years; n = 3), and late postmenopausal (>5 years; n = 10). Bone turnover markers were measured and the samples analyzed using microscopic computerized tomography and 3-dimensional bone morphometry.
The alveolar bone volume was significantly less in late postmenopausal women than in premenopausal ones. The trabeculae in early postmenopausal women were more separated and rod-like than in premenopausal ones (P < .05). Each alveolar bone parameter was significantly (P < .05) related to at least 1 bone turnover marker.
Alveolar cancellous bone structure begins changing even in early postmenopausal women, and this structure varies in close relationship to bone turnover markers.
在进行牙种植体预备时提取牙槽松质骨活检样本，以研究绝经引起的微观结构变化以及这些变化与骨转换标志物之间的关系。
研究对象为 18 名接受下颌种植体的女性：绝经前（n=5）、早绝经（≤5 年；n=3）和晚绝经（>5 年；n=10）。测量骨转换标志物，并使用显微镜计算机断层扫描和 3 维骨形态计量学对样本进行分析。
与绝经前女性相比，晚绝经女性的牙槽骨体积明显减少。与绝经前女性相比，早绝经女性的小梁更加分离和杆状（P<0.05）。每个牙槽骨参数均与至少 1 个骨转换标志物显著相关（P<0.05）。
牙槽松质骨结构甚至在早绝经女性中就开始发生变化，并且这种结构与骨转换标志物密切相关。
