Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029, Jiangsu, China.
Department of Oral and Maxillofacial Radiology, Affiliated Hospital of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029, Jiangsu, China.
Oral Radiol. 2019 Jan;35(1):16-22. doi: 10.1007/s11282-018-0322-3. Epub 2018 Mar 5.
This study was performed to analyze the aging-related changes of the female condylar bone mineral density (BMD) and trabecular structure by cone-beam computed tomography (CBCT), and determine whether the condylar structure shows obvious changes after menopause.
The CBCT images of 160 female patients who met the inclusion criteria for the study were collected and divided into four groups by age (20-29 years, 30-39 years, premenopausal, and postmenopausal groups). Computer processing software CT-Analyser (Version 1.15.2.2+; SkyScan, Antwerp, Belgium) was used to measure the condylar BMD and related indexes, namely the bone volume/tissue volume ratio (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), trabecular structure model index (SMI), and bone surface area/volume ratio (BS/BV). SPSS 12.0 (SPSS Inc., Chicago, IL, USA) was used to analyze the radiographic findings and statistical differences.
No significant differences were found between the bilateral condyles in each group (P > 0.05). BV/TV, Tb.N, and Tb.Th of the condyle decreased with age, and the postmenopausal group showed significantly different values for each index compared with the other groups (P < 0.01). Tb.Sp, SMI, and BS/BV of the condyle increased with age, and the postmenopausal group showed significantly different values for each index compared with the other groups (P < 0.01).
With increasing age, the female condylar bone volume decreases, the Tb.N and Tb.Th decrease, the gap between the trabecular bone increases, and plate-like trabecular bone gradually transforms into a rod-like form. These changes are much more obvious in postmenopausal women.
本研究通过锥形束 CT（CBCT）分析女性髁突骨密度（BMD）和小梁结构的年龄相关性变化，并确定髁突结构在绝经后是否发生明显变化。
收集符合纳入标准的 160 名女性患者的 CBCT 图像，按年龄分为四组（20-29 岁、30-39 岁、绝经前和绝经后组）。使用计算机处理软件 CT-Analyser（版本 1.15.2.2+；SkyScan，安特卫普，比利时）测量髁突 BMD 及相关指标，即骨体积/组织体积比（BV/TV）、骨小梁数量（Tb.N）、骨小梁厚度（Tb.Th）、骨小梁间距（Tb.Sp）、骨小梁结构模型指数（SMI）和骨表面积/体积比（BS/BV）。采用 SPSS 12.0（SPSS Inc.，芝加哥，IL，美国）分析影像学结果和统计学差异。
每组双侧髁突无显著差异（P>0.05）。随着年龄的增长，髁突的 BV/TV、Tb.N 和 Tb.Th 逐渐下降，绝经后组各指标值与其他组相比差异有统计学意义（P<0.01）。随着年龄的增长，髁突的 Tb.Sp、SMI 和 BS/BV 逐渐增加，绝经后组各指标值与其他组相比差异有统计学意义（P<0.01）。
随着年龄的增长，女性髁突骨量减少，Tb.N 和 Tb.Th 减少，骨小梁间隙增大，板状骨小梁逐渐转变为杆状骨小梁。这些变化在绝经后女性中更为明显。
