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跨物种的表观遗传学与发育可塑性。

Epigenetics and developmental plasticity across species.

机构信息

Department of Psychology, Columbia University, 1190 Amsterdam Avenue, Room 406 Schermerhorn Hall, New York, NY 10027, USA.

出版信息

Dev Psychobiol. 2013 Jan;55(1):33-41. doi: 10.1002/dev.21036. Epub 2012 Jun 18.

Abstract

Plasticity is a typical feature of development and can lead to divergent phenotypes. There is increasing evidence that epigenetic mechanisms, such as DNA methylation, are present across species, are modifiable by the environment, and are involved in developmental plasticity. Thus, in the context of the concept of developmental homology, epigenetic mechanisms may serve to create a process homology between species by providing a common molecular pathway through which environmental experiences shape development, ultimately leading to phenotypic diversity. This article will highlight evidence derived from across-species investigations of epigenetics, development, and plasticity which may contribute to our understanding of the homology that exists between species and between ancestors and descendants.

摘要

可塑性是发育的典型特征,可导致表型的分歧。越来越多的证据表明,表观遗传机制(如 DNA 甲基化)存在于各个物种中,可被环境修饰,并参与发育可塑性。因此,在发育同源性的概念中,表观遗传机制可以通过提供一条共同的分子途径,使环境经验塑造发育,从而导致表型多样性,从而在物种之间创造出过程同源性。本文将重点介绍来自跨物种的表观遗传学、发育和可塑性研究的证据,这些证据可能有助于我们理解物种之间以及祖先和后代之间存在的同源性。

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