Department of Biobehavioral Health Science, University of Illinois at Chicago College of Nursing, Chicago, Illinois (Dr Fritschi, Dr Quinn, Dr Hacker, Dr Wang, Dr Ferrans)
Marcella Niehoff School of Nursing, Loyola University, Chicago, Illinois (Dr Penckofer)
Diabetes Educ. 2012 Sep-Oct;38(5):662-72. doi: 10.1177/0145721712450925. Epub 2012 Jun 19.
The purpose of this study was to explore the relationship between fatigue and physiological, psychological, and lifestyle phenomena in women with type 2 diabetes (T2DM) in order to establish the magnitude and correlates of fatigue in women with T2DM and explore the interrelationships between fatigue and specific diabetes-related factors that may be associated with increased levels of fatigue. These factors included physiological factors (glucose control, diabetes symptoms), psychological factors (diabetes emotional distress, depressive symptoms in general), and lifestyle factors (body mass index, physical activity).
A cross-sectional, descriptive design was used. Women who reported conditions known to cause fatigue were excluded. Physiological measures included fasting blood glucose (FBG), hemoglobin A1C (A1C), glucose variability, and body mass index (BMI). Women completed questionnaires about health, fatigue levels, diabetes symptoms, diabetes emotional distress, depressive symptoms, physical activity, and current diabetes self-care practices. A subset of the women wore a Medtronic Gold CGM sensor for 3 days for assessment of glucose variability.
Eighty-three women aged 40 to 65 years with T2DM completed the study. Fatigue was significantly related to diabetes symptoms, diabetes emotional distress, depressive symptoms, higher BMI, and reduced physical activity. There was no relationship between fatigue and FBG or A1C. The strongest explanatory factors for fatigue were diabetes symptoms, depressive symptoms, and BMI, which accounted for 48% of the variance in fatigue scores. Glucose variability was not significantly associated with fatigue in these women.
Fatigue is a persistent clinical complaint among women with T2DM and may signal the presence of physiological, psychological, and lifestyle-related phenomena that could undermine diabetes health outcomes.
本研究旨在探讨 2 型糖尿病（T2DM）女性的疲劳与生理、心理和生活方式现象之间的关系，以确定 T2DM 女性疲劳的程度和相关性，并探讨疲劳与特定与糖尿病相关的因素之间的相互关系，这些因素可能与疲劳水平的增加有关。这些因素包括生理因素（血糖控制、糖尿病症状）、心理因素（糖尿病情绪困扰、一般抑郁症状）和生活方式因素（体重指数、身体活动）。
采用横断面描述性设计。排除报告已知导致疲劳的疾病的女性。生理指标包括空腹血糖（FBG）、糖化血红蛋白（A1C）、血糖变异性和体重指数（BMI）。女性完成有关健康、疲劳水平、糖尿病症状、糖尿病情绪困扰、抑郁症状、身体活动和当前糖尿病自我护理实践的问卷。其中一部分女性佩戴 Medtronic Gold CGM 传感器 3 天，以评估血糖变异性。
83 名年龄在 40 至 65 岁之间的 T2DM 女性完成了研究。疲劳与糖尿病症状、糖尿病情绪困扰、抑郁症状、较高的 BMI 和减少的身体活动显著相关。疲劳与 FBG 或 A1C 之间没有关系。疲劳的最强解释因素是糖尿病症状、抑郁症状和 BMI，它们占疲劳评分方差的 48%。在这些女性中，血糖变异性与疲劳没有显著相关性。
疲劳是 T2DM 女性持续存在的临床主诉，可能表明存在生理、心理和生活方式相关现象，这些现象可能会破坏糖尿病的健康结局。
