Women's College Research Institute, Women's College Hospital, 790 Bay Street, 7th Floor, Toronto, Ontario, Canada.
Gynecol Oncol. 2012 Oct;127(1):83-7. doi: 10.1016/j.ygyno.2012.05.038. Epub 2012 Jun 16.
Ovarian cancer is a highly fatal gynecologic malignancy. Prognosis is primarily based on clinicopathologic features. There is interest in the role of modifiable factors including overweight and obesity, although data to date have been inconclusive. Here we evaluate the relationship between body size and ovarian cancer survival among 1423 women diagnosed with epithelial ovarian cancer in a large population-based study.
Information on risk factors and characteristics was collected by telephone. Vital status was determined both by computerized record-linkage and by chart review. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for height, weight and body mass index (BMI) in association with ovarian cancer-specific mortality.
Height, weight and BMI 5 years prior to diagnosis did not significantly predict ovarian cancer survival in this study. The HR for ovarian cancer-specific mortality for women with a weight of >61 kg compared with >50-55 kg was 0.91 (95%CI 0.71-1.20). The HR among women with a BMI≥30 kg/m2 compared to 18.5-<25 kg/m2 was 1.11 (95%CI 0.87-1.42). These findings did not vary by histologic subtype.
Our results do not support a role of height, adult weight or adiposity in ovarian cancer prognosis.
卵巢癌是一种致命的妇科恶性肿瘤。预后主要基于临床病理特征。人们对可改变因素（包括超重和肥胖）的作用很感兴趣，尽管迄今为止数据尚无定论。在此，我们在一项大型基于人群的研究中，评估了 1423 名上皮性卵巢癌患者的体型与卵巢癌生存之间的关系。
通过电话收集了风险因素和特征信息。通过计算机记录链接和图表审查确定了存活状态。Cox 比例风险模型用于估计身高、体重和体重指数（BMI）与卵巢癌特异性死亡率之间的风险比（HR）和 95%置信区间（CI）。
在本研究中，诊断前 5 年的身高、体重和 BMI 并未显著预测卵巢癌的生存。与>50-55kg 相比，体重>61kg 的女性卵巢癌特异性死亡率的 HR 为 0.91（95%CI 0.71-1.20）。与 18.5-<25kg/m2 相比，BMI≥30kg/m2 的女性的 HR 为 1.11（95%CI 0.87-1.42）。这些发现与组织学亚型无关。
我们的结果不支持身高、成年体重或肥胖与卵巢癌预后有关。
