Department of Public Health and General Practice, Norwegian University of Science and Technology, PO Box 8904 MTFS, 7491, Trondheim, Norway.
Int Breastfeed J. 2012 Jun 19;7(1):8. doi: 10.1186/1746-4358-7-8.
Lactation has beneficial short term effects on maternal metabolic health, but the long term effects are less well known.
We studied the association between lifetime duration of lactation and cardiovascular risk factors in mothers later in life among 21,368 parous women aged 20 to 85 years attending the second Nord-Trøndelag Health Study (HUNT2) in 1995-1997, Norway, a cross-sectional population-based study. General linear modelling was used to calculate mean values of known cardiovascular risk factor levels in five categories of lifetime duration of lactation. Logistic regression was conducted to estimate odds ratios of hypertension, obesity and diabetes.
Among women aged 50 years or younger, lifetime duration of lactation was significantly and inversely associated with body mass index (P-trend, < 0.001), waist circumference (P-trend, < 0.001), systolic and diastolic blood pressure (both P-trends, < 0.001), and serum levels of triglycerides, total cholesterol and low density lipoprotein cholesterol (all P-trends, < 0.001) after adjustment for covariates. Parous women aged 50 years or younger who had never lactated had higher prevalence of hypertension, obesity and diabetes. In this age group, compared to women who had lactated for 24 months or more, parous women who had never lactated had an OR for hypertension of 1.88 (95% CI 1.41, 2.51), an OR for obesity of 3.37 (95% CI 2.51, 4.51) and an OR for diabetes of 5.87 (95% CI 2.25, 15.3). Among women older than 50 years there were no clear associations.
Lifetime duration of lactation was associated with long term reduced cardiovascular risk levels in mothers aged 50 years or younger.
哺乳对产妇短期的新陈代谢健康有益，但长期影响则不太明确。
我们研究了在挪威特隆赫姆 2 号健康研究（HUNT2）中，21368 名 20 至 85 岁、生育过的女性，一生中哺乳时间的长短与晚年心血管危险因素之间的关联。该研究为横断面的基于人群的研究，于 1995 年至 1997 年入组。采用一般线性模型计算五个类别的一生中哺乳时间的已知心血管危险因素水平的平均值。采用 logistic 回归估计高血压、肥胖和糖尿病的比值比。
在 50 岁及以下的女性中，一生中哺乳时间与体重指数（P 趋势，<0.001）、腰围（P 趋势，<0.001）、收缩压和舒张压（均 P 趋势，<0.001）以及血清甘油三酯、总胆固醇和低密度脂蛋白胆固醇（均 P 趋势，<0.001）呈显著负相关，经协变量调整后。50 岁及以下从未哺乳的生育过的女性高血压、肥胖和糖尿病的发病率更高。在这个年龄组中，与哺乳 24 个月或更长时间的女性相比，从未哺乳的生育过的女性高血压的比值比为 1.88（95%CI 1.41，2.51），肥胖的比值比为 3.37（95%CI 2.51，4.51），糖尿病的比值比为 5.87（95%CI 2.25，15.3）。在 50 岁以上的女性中，没有明显的相关性。
一生中哺乳时间与 50 岁及以下母亲的长期心血管风险降低相关。
