Department of Public Health and General Practice, Norwegian University of Science and Technology, PO Box 8904 MTFS, 7491 Trondheim, Norway.
BMC Public Health. 2013 Nov 13;13:1070. doi: 10.1186/1471-2458-13-1070.
Recent studies suggest that lactation has long-term effects on risk for cardiovascular disease in women, but the effects on cardiovascular mortality are less well known.
In a Norwegian population-based prospective cohort study, we studied the association of lifetime duration of lactation with cardiovascular mortality in 21,889 women aged 30 to 85 years who attended the second Nord-Trøndelag Health Survey (HUNT2) in 1995-1997. The cohort was followed for mortality through 2010 by a linkage with the Cause of Death Registry. Adjusted hazard ratios (HR) for death from all causes and cardiovascular disease were calculated using Cox regression.
During follow-up, 1,246 women died from cardiovascular disease. Parous women younger than 65 years who had never lactated had a higher cardiovascular mortality than the reference group of women who had lactated 24 months or more (HR 2.77, 95% confidence interval [CI]: 1.28, 5.99). There was some evidence of a U-shaped association, where women who reported lactating 7-12 months had a HR of 0.55 (95% CI: 0.27, 1.09). No clear associations were observed among women 65 years or older.
Excess cardiovascular mortality rates were observed among parous women younger than 65 years who had never lactated. These findings support the hypothesis that lactation may have long-term influences on maternal cardiovascular health.
最近的研究表明，哺乳对女性心血管疾病的风险有长期影响，但心血管死亡率的影响尚不清楚。
在一项挪威基于人群的前瞻性队列研究中，我们研究了终生哺乳时间与年龄在 30 至 85 岁之间、参加了 1995-1997 年第二次北特伦德拉格健康调查（HUNT2）的 21889 名女性的心血管死亡率之间的关联。通过与死因登记处的链接，对该队列进行了至 2010 年的死亡率随访。使用 Cox 回归计算所有原因和心血管疾病死亡的调整后的危险比（HR）。
在随访期间，有 1246 名女性死于心血管疾病。年龄小于 65 岁的多产妇从未哺乳的女性比参考组（哺乳 24 个月或以上的女性）的心血管死亡率更高（HR 2.77，95%置信区间[CI]：1.28，5.99）。有一些证据表明存在 U 型关联，报告哺乳 7-12 个月的女性 HR 为 0.55（95%CI：0.27，1.09）。在 65 岁或以上的女性中未观察到明确的关联。
在从未哺乳的年龄小于 65 岁的多产妇中观察到心血管死亡率过高。这些发现支持了哺乳可能对产妇心血管健康有长期影响的假说。
