Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Int J Dermatol. 2012 Jul;51(7):761-70. doi: 10.1111/j.1365-4632.2011.05272.x.
Hyperpigmentation of the lips is a common condition. It is associated with a wide variety of conditions that include physiologic changes, genodermatoses, inflammatory diseases, endocrinologic disorders, drugs and chemicals, benign and malignant neoplasm, and other non-melanotic conditions. The aim of this article is to provide a clinical approach to hyperpigmented lesions on the lips based on the extent of lesions, the age of onset, and associated systemic involvements. In this review, we present an algorithm to guide the diagnosis of and plan for therapeutic intervention for pigmented lesions of the lips. The algorithm is based on the typical clinical presentation of each entity and should not be taken as an absolute indicator of diagnosis. Although the differences in color can help to differentiate among pigmented lesions, the interpretation of color can be subjective and is influenced by the amount and location of the pigment within the mucosa. The limitations of this review are that some data are based on case reports and small case series that may not reflect true association.
嘴唇色素沉着是一种常见的病症。它与多种疾病有关，包括生理变化、遗传性皮肤病、炎症性疾病、内分泌紊乱、药物和化学物质、良性和恶性肿瘤以及其他非黑色素瘤疾病。本文旨在根据病变的范围、发病年龄和相关的全身受累情况，为嘴唇上的色素沉着病变提供一种临床处理方法。在本综述中，我们提出了一种用于指导嘴唇色素沉着病变诊断和治疗干预计划的算法。该算法基于每个实体的典型临床表现，不应被视为诊断的绝对指标。尽管颜色的差异有助于区分色素沉着病变，但颜色的解释可能是主观的，并且受到黏膜内色素的数量和位置的影响。本综述的局限性在于，一些数据基于病例报告和小病例系列，可能无法反映真实的关联。
