Othman Shah Farez, Manan Faudziah Abd, Zulkarnain Ahmad Iskandar, Mohamad Zainal, Ariffin Azrin E
Faculty of Optometry & Vision Sciences, SEGi University College, Selangor, Malaysia.
Clin Exp Optom. 2012 Sep;95(5):484-91. doi: 10.1111/j.1444-0938.2012.00752.x. Epub 2012 Jun 21.
This study aimed to determine the relationship between macular thickness and spherical equivalent refraction (SER), axial length (AL) and vitreous chamber depth (VCD) in Malay subjects.
Sixty-three subjects (aged 19-24 years) with a mean SER of -1.79 ± 2.24 D, mean axial length of 24.26 ± 1.35 mm and mean vitreous chamber depth of 17.02 ± 1.33 mm were included in this clinical cross-sectional study. Stratus optical coherence tomography (Time Domain optical coherence tomography) was used to determine the thickness of the outer macular (perifovea) and inner macular (parafovea) at four different locations, that is, temporal, superior, nasal and inferior quadrants and also the fovea itself.
Positive correlations were found between the outer macular (perifovea) thickness and SER at the temporal (R = 0.47, p < 0.05), superior (R = 0.36, p < 0.05) and inferior (R = 0.31, p < 0.05) quadrants. Foveal thickness was also positively correlated with AL (R = 0.34, p < 0.05) and VCD (R = 0.32, p < 0.05). Negative correlations were found between outer macular thickness and axial length at the temporal (R = -0.46, p < 0.05), superior (R = -0.27, p < 0.05), nasal (R = -0.25, p < 0.05) and inferior (R = -0.36, p < 0.05) quadrants. Negative correlations were also found between outer macular thickness and VCD at the temporal (R = -0.51, p < 0.05), superior (R = -0.32, p < 0.05), nasal (R = -0.31, p < 0.05) and inferior (R = -0.40, p < 0.05) quadrants.
This study shows that the degree of myopia and elongation of the globe are associated with thinning of most areas of the perifovea. A trend for foveal thickening in the high myopia group is also inferred, although this does not apply to the low and moderate myopia groups.
本研究旨在确定马来受试者黄斑厚度与等效球镜度（SER）、眼轴长度（AL）和玻璃体腔深度（VCD）之间的关系。
本临床横断面研究纳入了63名年龄在19至24岁之间的受试者，其平均SER为-1.79±2.24 D，平均眼轴长度为24.26±1.35 mm，平均玻璃体腔深度为17.02±1.33 mm。使用Stratus光学相干断层扫描（时域光学相干断层扫描）来确定黄斑外层（中心凹周围）和黄斑内层（中心凹旁）在四个不同位置，即颞侧、上方、鼻侧和下方象限以及中心凹本身的厚度。
在颞侧（R = 0.47，p < 0.05）、上方（R = 0.36，p < 0.05）和下方（R = 0.31，p < 0.05）象限，黄斑外层（中心凹周围）厚度与SER之间存在正相关。中心凹厚度也与AL（R = 0.34，p < 0.05）和VCD（R = 0.32，p < 0.05）呈正相关。在颞侧（R = -0.46，p < 0.05）、上方（R = -0.27，p < 0.05）、鼻侧（R = -0.25，p < 0.05）和下方（R = -0.36，p < 0.05）象限，黄斑外层厚度与眼轴长度之间存在负相关。在颞侧（R = -0.51，p < 0.05）、上方（R = -0.32，p < 0.05）、鼻侧（R = -0.31，p < 0.
