Lorenzi M, Vannoni D, Leoncini R, Caldarone R, Marinello E
Tumori. 1987 Jun 30;73(3):289-94. doi: 10.1177/030089168707300313.
Plasma levels and urinary excretion of oxypurines--hypoxanthine and xanthine--were evaluated by reverse-phase high-pressure liquid chromatography in 13 patients affected by gastric tumors and in 19 colorectal tumor-bearing patients. Preliminary results indicate higher values of urinary xanthine and an increase in the xanthine/hypoxanthine ratio in cancer patients. The increase was not generalized to all subjects, and did not appear related either to the stage of the disease or to CEA values. The limits within which the determination of urinary oxypurines can be employed as a tumor marker are discussed.
采用反相高效液相色谱法评估了13例胃癌患者和19例结直肠癌患者血浆中氧嘌呤（次黄嘌呤和黄嘌呤）水平及尿排泄情况。初步结果显示，癌症患者尿黄嘌呤值较高，且黄嘌呤/次黄嘌呤比值升高。这种升高并非在所有受试者中普遍存在，且似乎与疾病分期或癌胚抗原（CEA）值均无关。本文讨论了将尿氧嘌呤测定用作肿瘤标志物的适用范围。
