Wadsack Christian, Desoye Gernot, Hiden Ursula
Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria.
Wien Med Wochenschr. 2012 May;162(9-10):220-4. doi: 10.1007/s10354-012-0075-2.
This review aims to provide a comprehensive summary of the aspects of endothelial and vascular dysfunction in the feto-placental vasculature occurring in pregnancy pathologies. This endothelium is continuous with the fetal circulation. Its function and potential dysfunction in pathologies will have a profound impact on fetal development. Gestational diabetes mellitus represents one of these pathologies, in which its associated metabolic derangements will alter feto-placental endothelial functions. These, in turn, may result in functional changes of the placenta, which may entail impaired fetal development. By contrast, changes in the feto-placental vasculature observed in cases of fetal growth restriction and preeclampsia may be causative (fetal growth restriction) or secondary (preeclampsia) for the pathology.
本综述旨在全面总结妊娠病理状态下胎儿 - 胎盘血管系统中内皮功能和血管功能障碍的各个方面。这种内皮与胎儿循环系统相连。其在病理状态下的功能及潜在功能障碍将对胎儿发育产生深远影响。妊娠期糖尿病就是其中一种病理状态，其相关的代谢紊乱会改变胎儿 - 胎盘的内皮功能。进而，这些改变可能导致胎盘功能变化，这可能会影响胎儿发育。相比之下，在胎儿生长受限和子痫前期病例中观察到的胎儿 - 胎盘血管系统变化可能是该病理状态的病因（胎儿生长受限）或继发因素（子痫前期）。
