Department of Molecular Biotechnology and Health Sciences, University of Torino, 10124 Torino, Italy.
Aston Medical Research Institute, Aston Medical School, Aston University, Birmingham B4 7ET, UK.
Int J Mol Sci. 2021 May 20;22(10):5402. doi: 10.3390/ijms22105402.
Angiogenesis is one of the main processes that coordinate the biological events leading to a successful pregnancy, and its imbalance characterizes several pregnancy-related diseases, including preeclampsia. Intracellular interactions via extracellular vesicles (EVs) contribute to pregnancy's physiology and pathophysiology, and to the fetal-maternal interaction. The present review outlines the implications of EV-mediated crosstalk in the angiogenic process in healthy pregnancy and its dysregulation in preeclampsia. In particular, the effect of EVs derived from gestational tissues in pro and anti-angiogenic processes in the physiological and pathological setting is described. Moreover, the application of EVs from placental stem cells in the clinical setting is reported.
血管生成是协调导致成功妊娠的生物学事件的主要过程之一，其失衡特征是几种与妊娠相关的疾病，包括子痫前期。通过细胞外囊泡 (EV) 的细胞内相互作用有助于妊娠的生理学和病理生理学以及胎儿-母体相互作用。本综述概述了 EV 介导的细胞间通讯在健康妊娠中的血管生成过程中的意义及其在子痫前期中的失调。特别是，描述了来源于妊娠组织的 EV 在生理和病理环境中的促血管生成和抗血管生成过程中的作用。此外，还报告了胎盘干细胞衍生的 EV 在临床环境中的应用。
