低血清谷胱甘肽过氧化物酶活性与低 HDLc 个体心血管死亡率增加相关。
Low serum glutathione peroxidase activity is associated with increased cardiovascular mortality in individuals with low HDLc's.
机构信息
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America.
出版信息
PLoS One. 2012;7(6):e38901. doi: 10.1371/journal.pone.0038901. Epub 2012 Jun 15.
BACKGROUND
Since oxidized LDL is thought to initiate atherosclerosis and the serum glutathione peroxidase (GPx3) reduces oxidized lipids, we investigated whether high GPx3 activity reduces cardiovascular disease (CVD) mortality.
METHODS
We determined GPx3 in stored samples from the Minnesota Heart Survey of 130 participants who after 5 to 12 years of follow-up had died of CVD and 240 controls. Participants were 26 to 85 years old and predominantly white. In a nested case-control, study we performed logistic regressions to calculate odds ratios (OR) adjusted for age, sex, baseline year, body mass index, smoking, alcohol intake, physical activity, total and HDL cholesterols, systolic blood pressure, serum glucose and gamma glutamyltransferase (GTT) activity. The referent was the quartile with the highest GPx3 activity (quartile 4).
RESULTS
OR's for CVD mortality for increasing quartiles of GPx3 were 2.37, 2.14, 1.83 and 1.00 (P for trend 0.02). This inverse correlation was confined to those with HDLc's below the median (P for interaction, 0.006). The OR's for increasing quartiles of GPx3 in this group were 6.08, 5.00, 3.64 and 1.00 (P for trend, 0.002).
CONCLUSIONS
Individuals with both low HDLc and GPx3 activity are at markedly increased risk for death from CVD.
背景
由于氧化型低密度脂蛋白（LDL）被认为是动脉粥样硬化的起始因子，而血清谷胱甘肽过氧化物酶（GPx3）可以减少氧化脂质，因此我们研究了高 GPx3 活性是否可以降低心血管疾病（CVD）死亡率。
方法
我们测定了来自明尼苏达州心脏调查（Minnesota Heart Survey）的 130 名参与者的储存样本中的 GPx3，这些参与者在随访 5 至 12 年后死于 CVD，另外还有 240 名对照者。参与者年龄在 26 至 85 岁之间，主要为白人。在一项巢式病例对照研究中，我们进行了逻辑回归分析，以计算调整年龄、性别、基线年份、体重指数、吸烟、饮酒、身体活动、总胆固醇和高密度脂蛋白胆固醇、收缩压、血清葡萄糖和γ-谷氨酰转移酶（GGT）活性后的比值比（OR）。参考值为 GPx3 活性最高的四分位数（四分位数 4）。
结果
随着 GPx3 四分位数的增加，CVD 死亡率的 OR 分别为 2.37、2.14、1.83 和 1.00（趋势 P 值为 0.02）。这种负相关仅局限于 HDLc 低于中位数的人群（交互作用 P 值为 0.006）。在该组中，随着 GPx3 四分位数的增加，OR 分别为 6.08、5.00、3.64 和 1.00（趋势 P 值为 0.002）。
结论
同时具有低 HDLc 和 GPx3 活性的个体发生 CVD 死亡的风险显著增加。
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