肿瘤微环境中的串扰介导胰腺癌中的 Th2 型炎症。
Cross-talk within the tumor microenvironment mediates Th2-type inflammation in pancreatic cancer.
机构信息
Tumor Immunology Unit; Division of Immunology; Transplantation and Infectious Diseases; San Raffaele Scientific Institute; Milan, Italy.
出版信息
Oncoimmunology. 2012 Jan 1;1(1):89-91. doi: 10.4161/onci.1.1.17939.
Abstract
Th2-type inflammation has been proposed to facilitate tumor growth. In De Monte et al. (J Exp Med 208:469-478, 2011) we identify in pancreatic cancer a complex cytokine/chemokine cross-talk within the tumor microenvironment mediating Th2 immune-deviation and show that the ratio of Th2/Th1 tumor infiltrating lymphocytes is an independent predictive marker of patients survival.
摘要
Th2 型炎症被认为有助于肿瘤生长。在 De Monte 等人的研究中（J Exp Med 208:469-478, 2011），我们在胰腺癌中发现了肿瘤微环境中复杂的细胞因子/趋化因子相互作用，介导了 Th2 免疫偏离，并表明 Th2/Th1 肿瘤浸润淋巴细胞的比值是患者生存的独立预测标志物。
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本文引用的文献
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