Tumor Immunology Unit, Transplantation and Infectious Diseases, San Raffaele Scientific Institute Milan, Italy ; Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute Milan, Italy.
Front Physiol. 2013 Aug 9;4:210. doi: 10.3389/fphys.2013.00210. eCollection 2013.
Pancreatic cancer is a devastating disease with dismal prognosis. The tumor microenvironment is composed by multiple cell types, molecular factors, and extracellular matrix forming a strong desmoplastic reaction, which is a hallmark of the disease. A complex cross-talk between tumor cells and the stroma exists with reciprocal influence that dictates tumor progression and ultimately the clinical outcome. In this context, tumor infiltrating immune cells through secretion of chemokine and cytokines exert an important regulatory role. Here we review the correlation between the immune infiltrates, evaluated on tumor samples of pancreatic cancer patients underwent surgical resection, and disease free and/or overall survival after surgery. Specifically, we focus on tumor infiltrating lymphocytes (TILs), mast cells (MCs) and macrophages that all contribute to a Th2-type inflammatory and immunosuppressive microenvironment. In these patients tumor immune infiltrates not only do not contribute to disease eradication but rather the features of Th2-type inflammation and immunosuppression is significantly associated with more rapid disease progression and reduced survival.
胰腺癌是一种预后极差的毁灭性疾病。肿瘤微环境由多种细胞类型、分子因子和细胞外基质组成，形成强烈的促结缔组织反应，这是该疾病的一个标志。肿瘤细胞与基质之间存在着复杂的相互作用，这种相互作用会相互影响，决定肿瘤的进展，并最终影响临床结果。在这种情况下，肿瘤浸润免疫细胞通过分泌趋化因子和细胞因子发挥重要的调节作用。在这里，我们回顾了在接受手术切除的胰腺癌患者的肿瘤样本中评估的免疫浸润与手术后无病和/或总生存率之间的相关性。具体来说，我们关注的是肿瘤浸润淋巴细胞（TILs）、肥大细胞（MCs）和巨噬细胞，它们都有助于 Th2 型炎症和免疫抑制微环境。在这些患者中，肿瘤免疫浸润不仅不能有助于疾病的根除，而且 Th2 型炎症和免疫抑制的特征与更快的疾病进展和降低的生存率显著相关。
