Cancer Immunology and Immunotherapy Center; Saint Savas Cancer Hospital; Athens, Greece.
Oncoimmunology. 2012 Mar 1;1(2):205-207. doi: 10.4161/onci.1.2.18398.
Repetitive infusions of ex vivo expanded NK cells induced antitumor T-cell responses in a metastatic lung cancer mouse model. These were further potentiated by Treg depletion. Thus the combination of NK cell-based immunotherapy with other treatment modalities in the direction of adaptive response enhancement might promote long lasting antitumor immunity.
重复输注体外扩增的自然杀伤（NK）细胞可在转移性肺癌小鼠模型中诱导抗肿瘤 T 细胞反应，而 Treg 细胞耗竭可进一步增强这种反应。因此，基于 NK 细胞的免疫疗法与其他治疗方式相结合，以增强适应性反应，可能会促进长期的抗肿瘤免疫。
