IL-33/ST2 轴在肿瘤的先天和获得性免疫中的作用。
IL-33/ST2 axis in innate and acquired immunity to tumors.
机构信息
Center for Molecular Medicine and Stem Cell Research; Faculty of Medicine; University of Kragujevac; Kragulevac, Serbia.
出版信息
Oncoimmunology. 2012 Mar 1;1(2):229-231. doi: 10.4161/onci.1.2.18131.
Abstract
Interleukin-33, a ligand for ST2/T1, has an important role in allergy, autoimmunity and inflammation. The role of IL-33/ST2 axis in cancer is not elucidated. Using metastatic breast cancer model we provide evidence that lack of ST2 signaling led to reduced tumor growth and metastasis and enhanced anti-tumor immunity.
摘要
白细胞介素 33（IL-33）是 ST2/T1 的配体，在过敏、自身免疫和炎症中具有重要作用。IL-33/ST2 轴在癌症中的作用尚未阐明。本研究使用转移性乳腺癌模型提供了证据，表明缺乏 ST2 信号会导致肿瘤生长和转移减少，并增强抗肿瘤免疫。
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