• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

IL-33/ST2 轴在肿瘤的先天和获得性免疫中的作用。

IL-33/ST2 axis in innate and acquired immunity to tumors.

机构信息

Center for Molecular Medicine and Stem Cell Research; Faculty of Medicine; University of Kragujevac; Kragulevac, Serbia.

出版信息

Oncoimmunology. 2012 Mar 1;1(2):229-231. doi: 10.4161/onci.1.2.18131.

DOI:10.4161/onci.1.2.18131
PMID:22720252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3376988/
Abstract

Interleukin-33, a ligand for ST2/T1, has an important role in allergy, autoimmunity and inflammation. The role of IL-33/ST2 axis in cancer is not elucidated. Using metastatic breast cancer model we provide evidence that lack of ST2 signaling led to reduced tumor growth and metastasis and enhanced anti-tumor immunity.

摘要

白细胞介素 33（IL-33）是 ST2/T1 的配体，在过敏、自身免疫和炎症中具有重要作用。IL-33/ST2 轴在癌症中的作用尚未阐明。本研究使用转移性乳腺癌模型提供了证据，表明缺乏 ST2 信号会导致肿瘤生长和转移减少，并增强抗肿瘤免疫。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/3376988/dbac90446d88/onci-1-229-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/3376988/dbac90446d88/onci-1-229-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21aa/3376988/dbac90446d88/onci-1-229-g1.jpg

相似文献

1
IL-33/ST2 axis in innate and acquired immunity to tumors.IL-33/ST2 轴在肿瘤的先天和获得性免疫中的作用。
Oncoimmunology. 2012 Mar 1;1(2):229-231. doi: 10.4161/onci.1.2.18131.
2
Interleukin-33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells.白细胞介素-33/ST2 轴通过促进肿瘤内免疫抑制性和固有淋巴细胞的积累促进乳腺癌的生长和转移。
Int J Cancer. 2014 Apr 1;134(7):1669-82. doi: 10.1002/ijc.28481. Epub 2013 Oct 10.
3
Interleukin-33/ST2 axis promotes epithelial cell transformation and breast tumorigenesis via upregulation of COT activity.白细胞介素-33/ST2轴通过上调COT活性促进上皮细胞转化和乳腺肿瘤发生。
Oncogene. 2015 Sep 17;34(38):4928-38. doi: 10.1038/onc.2014.418. Epub 2014 Dec 22.
4
IL-33/ST2 axis in inflammation and immunopathology.IL-33/ST2 轴在炎症和免疫病理学中的作用。
Immunol Res. 2012 Apr;52(1-2):89-99. doi: 10.1007/s12026-012-8283-9.
5
Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction.白细胞介素1（IL-1）受体同源物T1/ST2激活的信号通路的特征。Jun N端激酶在IL-4诱导中的作用。
J Biol Chem. 2002 Dec 20;277(51):49205-11. doi: 10.1074/jbc.M209685200. Epub 2002 Oct 3.
6
Salidroside suppresses group 2 innate lymphoid cell-mediated allergic airway inflammation by targeting IL-33/ST2 axis.红景天苷通过靶向 IL-33/ST2 轴抑制 2 型固有淋巴细胞介导的过敏性气道炎症。
Int Immunopharmacol. 2020 Apr;81:106243. doi: 10.1016/j.intimp.2020.106243. Epub 2020 Feb 15.
7
IL-33 Receptor (ST2) Signalling is Important for Regulation of Th2-Mediated Airway Inflammation in a Murine Model of Acute Respiratory Syncytial Virus Infection.白细胞介素-33受体（ST2）信号传导对于急性呼吸道合胞病毒感染小鼠模型中Th2介导的气道炎症调节至关重要。
Scand J Immunol. 2015 Jun;81(6):494-501. doi: 10.1111/sji.12284.
8
IL-33 increases ST2 Tregs and promotes metastatic tumour growth in the lungs in an amphiregulin-dependent manner.白细胞介素-33以双调蛋白依赖的方式增加ST2调节性T细胞，并促进肺部转移性肿瘤生长。
Oncoimmunology. 2018 Oct 16;8(2):e1527497. doi: 10.1080/2162402X.2018.1527497. eCollection 2019.
9
IL-33/ST2 pathway contributes to metastasis of human colorectal cancer.白细胞介素-33/ST2通路促进人类结直肠癌转移。
Biochem Biophys Res Commun. 2014 Oct 24;453(3):486-92. doi: 10.1016/j.bbrc.2014.09.106. Epub 2014 Sep 30.
10
Decoding the IL-33/ST2 Axis: Its Impact on the Immune Landscape of Breast Cancer.解读白细胞介素-33/ST2轴：其对乳腺癌免疫格局的影响
Int J Mol Sci. 2023 Sep 13;24(18):14026. doi: 10.3390/ijms241814026.

引用本文的文献

1
Single-cell sequencing reveals the role of endothelial subsets in promoting early gastric cancer progression.单细胞测序揭示了内皮细胞亚群在促进早期胃癌进展中的作用。
Imeta. 2025 Jun 5;4(4):e70050. doi: 10.1002/imt2.70050. eCollection 2025 Aug.
2
Prognostic significance of IL-33 and ST2 expression in head and neck squamous cell carcinoma: a systematic review.IL-33和ST2表达在头颈部鳞状细胞癌中的预后意义：一项系统评价
Front Oral Health. 2025 Mar 24;6:1551781. doi: 10.3389/froh.2025.1551781. eCollection 2025.
3
IL-33/ST2 axis in diverse diseases: regulatory mechanisms and therapeutic potential.

本文引用的文献

1
The dual function cytokine IL-33 interacts with the transcription factor NF-κB to dampen NF-κB-stimulated gene transcription.双重功能细胞因子 IL-33 与转录因子 NF-κB 相互作用，以抑制 NF-κB 刺激的基因转录。
J Immunol. 2011 Aug 15;187(4):1609-16. doi: 10.4049/jimmunol.1003080. Epub 2011 Jul 6.
2
Protective role of IL-33/ST2 axis in Con A-induced hepatitis.IL-33/ST2 轴在 ConA 诱导的肝炎中的保护作用。
J Hepatol. 2012 Jan;56(1):26-33. doi: 10.1016/j.jhep.2011.03.022. Epub 2011 May 18.
3
Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway.
不同疾病中的白细胞介素-33/ST2轴：调控机制与治疗潜力
Front Immunol. 2025 Jan 24;16:1533335. doi: 10.3389/fimmu.2025.1533335. eCollection 2025.
4
Interleukin-33 Expression on Treatment Outcomes and Prognosis in Brazilian Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy.白细胞介素-33 在巴西新辅助化疗乳腺癌患者治疗结果和预后中的表达。
Int J Mol Sci. 2023 Nov 15;24(22):16326. doi: 10.3390/ijms242216326.
5
A comprehensive review of stroke-related signaling pathways and treatment in western medicine and traditional Chinese medicine.中西医中与中风相关的信号通路及治疗的综合综述。
Front Neurosci. 2023 Jun 7;17:1200061. doi: 10.3389/fnins.2023.1200061. eCollection 2023.
6
Interleukin-33: Friend or Foe in Gastrointestinal Tract Cancers?白细胞介素-33：在胃肠道肿瘤中是敌是友？
Cells. 2023 May 26;12(11):1481. doi: 10.3390/cells12111481.
7
Targeting Underlying Inflammation in Carcinoma Is Essential for the Resolution of Depressiveness.针对癌的潜在炎症是解决抑郁的关键。
Cells. 2023 Feb 23;12(5):710. doi: 10.3390/cells12050710.
8
Head and Neck Cancer Immunotherapy: Molecular Biological Aspects of Preclinical and Clinical Research.头颈癌免疫疗法：临床前和临床研究的分子生物学方面
Cancers (Basel). 2023 Jan 30;15(3):852. doi: 10.3390/cancers15030852.
9
The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis.维生素D补充剂对膝骨关节炎炎症介质表达的影响。
Immunol Res. 2023 Jun;71(3):442-450. doi: 10.1007/s12026-022-09354-0. Epub 2022 Dec 26.
10
Interleukin-33 and Soluble ST2 as Potential Biomarkers of Cancer in Opium Users: A Nested Case-Control Study.白细胞介素-33 和可溶性 ST2 作为阿片类药物使用者癌症的潜在生物标志物：一项巢式病例对照研究。
Iran J Med Sci. 2022 Nov;47(6):541-548. doi: 10.30476/IJMS.2021.92335.2360.
静脉注射丙种球蛋白通过一种新的 TH2 途径抑制炎症反应。
Nature. 2011 Jun 19;475(7354):110-3. doi: 10.1038/nature10134.
4
Thymic stromal lymphopoietin is a key mediator of breast cancer progression.胸腺基质淋巴细胞生成素是乳腺癌进展的关键介质。
J Immunol. 2011 May 15;186(10):5656-62. doi: 10.4049/jimmunol.1100463. Epub 2011 Apr 13.
5
ST2 deletion enhances innate and acquired immunity to murine mammary carcinoma.ST2 缺失增强了对小鼠乳腺癌的固有和获得性免疫。
Eur J Immunol. 2011 Jul;41(7):1902-12. doi: 10.1002/eji.201141417.
6
Disease-associated functions of IL-33: the new kid in the IL-1 family.IL-33 在疾病中的作用：IL-1 家族的新成员。
Nat Rev Immunol. 2010 Feb;10(2):103-10. doi: 10.1038/nri2692. Epub 2010 Jan 18.
7
Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma.抗白细胞介素-33抗体治疗可抑制过敏性哮喘小鼠模型中的气道炎症。
Biochem Biophys Res Commun. 2009 Aug 14;386(1):181-5. doi: 10.1016/j.bbrc.2009.06.008. Epub 2009 Jun 7.
8
Regulatory T cells and ST2 signaling control diabetes induction with multiple low doses of streptozotocin.调节性 T 细胞和 ST2 信号通路控制多次小剂量链脲佐菌素诱导的糖尿病。
Mol Immunol. 2009 Nov;47(1):28-36. doi: 10.1016/j.molimm.2008.12.023. Epub 2009 Apr 7.
9
Human IL-18 receptor and ST2L are stable and selective markers for the respective type 1 and type 2 circulating lymphocytes.人白细胞介素-18受体和ST2L分别是1型和2型循环淋巴细胞的稳定且特异性的标志物。
J Immunol. 2001 Aug 1;167(3):1238-44. doi: 10.4049/jimmunol.167.3.1238.
10
Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells.一种稳定的细胞表面分子在2型辅助性T细胞而非1型辅助性T细胞上的选择性表达。
J Exp Med. 1998 Mar 2;187(5):787-94. doi: 10.1084/jem.187.5.787.