非小细胞肺癌肿瘤微环境抑制 NK 细胞功能。
Tumor microenvironment in NSCLC suppresses NK cells function.
机构信息
Institut National de la Santé et de la Recherche Médicale (INSERM); Centre de Recherche des Cordeliers; Paris, France ; Université Pierre et Marie Curie; Paris, France.
出版信息
Oncoimmunology. 2012 Mar 1;1(2):244-246. doi: 10.4161/onci.1.2.18309.
Abstract
NK cells, which contribute to tumor immunosurveillance, are present in the microenvironment of Non-Small-Cell Lung Carcinoma. However, they display strongly altered phenotype with decreased expression of NKp30, NKp80, DNAM-1, CD16 and ILT2, and impaired cytotoxic functions. The possible mechanisms leading to these defects are discussed.
摘要
自然杀伤 (NK) 细胞有助于肿瘤免疫监视，存在于非小细胞肺癌的微环境中。然而，它们表现出强烈改变的表型，NKp30、NKp80、DNAM-1、CD16 和 ILT2 的表达降低，细胞毒性功能受损。讨论了导致这些缺陷的可能机制。
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