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非小细胞肺癌肿瘤微环境抑制 NK 细胞功能。

Tumor microenvironment in NSCLC suppresses NK cells function.

机构信息

Institut National de la Santé et de la Recherche Médicale (INSERM); Centre de Recherche des Cordeliers; Paris, France ; Université Pierre et Marie Curie; Paris, France.

出版信息

Oncoimmunology. 2012 Mar 1;1(2):244-246. doi: 10.4161/onci.1.2.18309.

DOI:10.4161/onci.1.2.18309
PMID:22720258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3377004/
Abstract

NK cells, which contribute to tumor immunosurveillance, are present in the microenvironment of Non-Small-Cell Lung Carcinoma. However, they display strongly altered phenotype with decreased expression of NKp30, NKp80, DNAM-1, CD16 and ILT2, and impaired cytotoxic functions. The possible mechanisms leading to these defects are discussed.

摘要

自然杀伤 (NK) 细胞有助于肿瘤免疫监视，存在于非小细胞肺癌的微环境中。然而，它们表现出强烈改变的表型，NKp30、NKp80、DNAM-1、CD16 和 ILT2 的表达降低，细胞毒性功能受损。讨论了导致这些缺陷的可能机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa73/3377004/0076d5613d95/onci-1-244-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa73/3377004/0076d5613d95/onci-1-244-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa73/3377004/0076d5613d95/onci-1-244-g1.jpg

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J Clin Invest. 2011 Sep;121(9):3609-22. doi: 10.1172/JCI45816. Epub 2011 Aug 15.
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Cancer Res. 2011 Aug 15;71(16):5412-22. doi: 10.1158/0008-5472.CAN-10-4179. Epub 2011 Jun 27.
3
Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors.
肿瘤介导的中性粒细胞极化及其治疗意义。
Int J Mol Sci. 2022 Mar 16;23(6):3218. doi: 10.3390/ijms23063218.
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Pharmaceutics. 2021 Oct 15;13(10):1689. doi: 10.3390/pharmaceutics13101689.
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Oncol Rep. 2021 Nov;46(5). doi: 10.3892/or.2021.8183. Epub 2021 Sep 9.
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Remodeling of Stromal Cells and Immune Landscape in Microenvironment During Tumor Progression.肿瘤进展过程中微环境中基质细胞和免疫格局的重塑
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