Watkins Stephanie K, Hurwitz Arthur A
Tumor Immunity and Tolerance Section; Laboratory of Molecular Immunoregulation; Cancer and Inflammation Program; NCI-Frederick; Frederick, MD USA.
Oncoimmunology. 2012 Mar 1;1(2):252-254. doi: 10.4161/onci.1.2.18241.
Recent findings demonstrate that dendritic cells in prostate tumors induce immune tolerance in tumor antigen-specific CD8(+) T cells. We propose that DC tolerogenicity can be regulated by expression of Foxo3; silencing Foxo3 expression enhances anti-tumor immune responses and renders FOXO3 a potential target for immunotherapy.
最近的研究结果表明，前列腺肿瘤中的树突状细胞可诱导肿瘤抗原特异性CD8(+) T细胞产生免疫耐受。我们认为，Foxo3的表达可调节树突状细胞的耐受性；沉默Foxo3的表达可增强抗肿瘤免疫反应，并使FOXO3成为免疫治疗的潜在靶点。
