Barkund Shravani, Shah Tejas, Ambatkar Nikhil, Gadgil Maithili, Joshi Kalpana
Department of Biotechnology, Sinhgad College of Engineering, Vadgaon Budruk, Pune, Maharashtra 411041, India.
Mol Biol Int. 2015;2015:638515. doi: 10.1155/2015/638515. Epub 2015 Dec 9.
Asthma is a chronic inflammatory disorder delineated by a heightened immunological response due to environmental or genetic factors. Single nucleotide polymorphism studies have shown that FOXO3a plays a pivotal role in maintaining immunoregulation. Polymorphism in FOXO3a has been linked to inflammatory diseases such as chronic obstructive pulmonary disease (COPD), Rheumatoid Arthritis, and Crohn's disease suggesting that FOXO3a may be associated with asthma. Airway inflammation in asthma is characterized by activation of T helper type 2 (Th2) T cells and Foxo family members are reported to play critical roles in the suppression of T cell activation. Thus this study was undertaken to investigate an association between single nucleotide polymorphism of the FOXO3a (rs13217795, C>T transition) gene and asthma in Indian population. To our knowledge we are the first ones reporting an association between FOXO3a and asthma.
哮喘是一种慢性炎症性疾病，由环境或遗传因素导致的免疫反应增强所引发。单核苷酸多态性研究表明，FOXO3a在维持免疫调节中起关键作用。FOXO3a的多态性与慢性阻塞性肺疾病（COPD）、类风湿性关节炎和克罗恩病等炎症性疾病有关，这表明FOXO3a可能与哮喘相关。哮喘中的气道炎症以2型辅助性T（Th2）细胞的激活为特征，并且据报道Foxo家族成员在抑制T细胞激活中起关键作用。因此，本研究旨在调查印度人群中FOXO3a基因的单核苷酸多态性（rs13217795，C>T转换）与哮喘之间的关联。据我们所知，我们是首个报道FOXO3a与哮喘之间存在关联的研究团队。
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