Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan.
Asian J Surg. 2012 Apr;35(2):81-7. doi: 10.1016/j.asjsur.2012.04.022. Epub 2012 May 26.
We retrospectively evaluated the usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery.
A total of 86 patients were given 12 mg of sennoside on the evening prior to resective surgery for colon cancer, followed by intravenous antimicrobial prophylaxis used on the day of surgery or until postoperative day 2.
The incidence of surgical site infection in the study group was 4.7%, which was comparable to that in the historical control patients (3.5%, p>0.99), who had received polyethylene glycol for mechanical bowel preparation prior to colon surgery. On multivariate logistic regression analysis, only body mass index (p=0.04) was an independent significant factor affecting the surgical site infection. The intraoperative spillage was not influenced by the presence of stenosis, although the amount of fecal matter was higher in the upstream colon segment (p<0.01) and downstream segment (p=0.07) in patients with a stenotic lesion occupying more than two-thirds of the lumen (n=29) than in those without such severe stenosis (n=57).
Sennoside seems to be an acceptable agent for mechanical bowel preparation even in patients with stenosis.
我们回顾性评估番泻苷在择期结肠癌手术前机械肠道准备中的作用。
总共 86 例患者在结肠癌切除术的前一天晚上给予 12mg 番泻苷，然后在手术当天或术后第 2 天给予静脉用抗菌预防药物。
研究组的手术部位感染发生率为 4.7%，与接受聚乙二醇进行机械肠道准备的历史对照患者（3.5%，p>0.99）相当。多变量逻辑回归分析显示，只有体重指数（p=0.04）是影响手术部位感染的独立显著因素。虽然在狭窄病变占据管腔三分之二以上的 29 例患者中，上游肠段（p<0.01）和下游肠段（p=0.07）的粪便量更高，但狭窄的存在并不影响术中渗漏。
番泻苷似乎是机械肠道准备的一种可接受的药物，即使在有狭窄的患者中也是如此。
