番泻苷与聚乙二醇作为择期结肠癌手术机械性肠道准备在手术部位感染风险及手术可行性方面的比较：一项随机对照试验
Comparison of the risk of surgical site infection and feasibility of surgery between sennoside versus polyethylene glycol as a mechanical bowel preparation of elective colon cancer surgery: a randomized controlled trial.
作者信息
Tajima Yusuke, Ishida Hideyuki, Yamamoto Azusa, Chika Noriyasu, Onozawa Hisashi, Matsuzawa Takeaki, Kumamoto Kensuke, Ishibashi Keiichiro, Mochiki Erito
机构信息
Department of General and Digestive Tract Surgery, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan.
出版信息
Surg Today. 2016 Jun;46(6):735-40. doi: 10.1007/s00595-015-1239-7. Epub 2015 Aug 30.
PURPOSE
To validate the usefulness of sennoside as a substitute for polyethylene glycol (PEG) as a mechanical bowel preparation (MBP) for elective colon cancer surgery.
METHODS
We performed a prospective randomized non-inferiority trial comparing the use of sennoside and PEG in MBP for elective colon cancer surgery, in terms of the risk of surgical site infection (SSI) and the feasibility of surgery.
RESULTS
The overall incidence of SSIs was 2.9 % in the sennoside group (n = 68) and 6.3 % in the PEG group (n = 63) with a difference of 3.4 % (95 % confidence interval 6.9-10.6 %). The intraoperative spillage of the stool materials in the sennoside and PEG groups was 4.4 and 3.1 %, respectively, and was not significantly different (p = 0.71), even the upstream stool consistency, was more frequently observed to be non-stool in the PEG group (65.1 vs. 30.9 %, p < 0.01).
CONCLUSION
MBP with sennoside could be a substitution for PEG in elective colon cancer surgery.
目的
验证番泻苷作为聚乙二醇（PEG）的替代品用于择期结肠癌手术机械性肠道准备（MBP）的有效性。
方法
我们进行了一项前瞻性随机非劣效性试验，比较番泻苷和PEG在择期结肠癌手术MBP中的应用，评估手术部位感染（SSI）风险和手术可行性。
结果
番泻苷组（n = 68）SSI总发生率为2.9%，PEG组（n = 63）为6.3%，差异为3.4%（95%置信区间6.9 - 10.6%）。番泻苷组和PEG组术中粪便物质溢出率分别为4.4%和3.1%，无显著差异（p = 0.71），即便PEG组上游粪便一致性更常观察到非粪便状态（65.1%对30.9%，p < 0.01）。
结论
番泻苷用于MBP可替代PEG用于择期结肠癌手术。
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