The University of Queensland, School of Biomedical Sciences, St Lucia, Brisbane, QLD 4072, Australia.
J Neuroinflammation. 2012 Jun 21;9:137. doi: 10.1186/1742-2094-9-137.
The complement system, a major component of the innate immune system, is becoming increasingly recognised as a key participant in physiology and disease. The awareness that immunological mediators support various aspects of both normal central nervous system (CNS) function and pathology has led to a renaissance of complement research in neuroscience. Various studies have revealed particularly novel findings on the wide-ranging involvement of complement in neural development, synapse elimination and maturation of neural networks, as well as the progression of pathology in a range of chronic neurodegenerative disorders, and more recently, neurotraumatic events, where rapid disruption of neuronal homeostasis potently triggers complement activation. The purpose of this review is to summarise recent findings on complement activation and acquired brain or spinal cord injury, i.e. ischaemic-reperfusion injury or stroke, traumatic brain injury (TBI) and spinal cord injury (SCI), highlighting the potential for complement-targeted therapeutics to alleviate the devastating consequences of these neurological conditions.
补体系统是先天免疫系统的主要组成部分，它在生理和疾病中的关键作用正日益受到关注。人们逐渐认识到免疫介质支持中枢神经系统（CNS）正常功能和病理的各个方面，这导致了补体在神经科学中的研究复兴。各种研究揭示了补体在神经发育、突触消除和神经网络成熟以及一系列慢性神经退行性疾病中的广泛作用的新发现，最近还揭示了神经创伤事件中的新发现，其中神经元内稳态的迅速破坏有力地触发了补体的激活。本文综述了补体激活与获得性脑或脊髓损伤（即缺血再灌注损伤或中风、创伤性脑损伤（TBI）和脊髓损伤（SCI））的最新发现，强调了补体靶向治疗的潜力，以减轻这些神经状况的毁灭性后果。
