Pérez-Torres Israel, Ruiz-Ramírez Angélica, Baños Guadalupe, El-Hafidi Mohammed
Department of Biomedicine Cardiovascular, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico.
Cardiovasc Hematol Agents Med Chem. 2013 Mar;11(1):25-37. doi: 10.2174/1871525711311010006.
Metabolic syndrome (MS) is an obesity-associated collection of disorders, each of which contributes to cardiovascular risk. For patients with MS, it is difficult to follow a diet/exercise regime that would improve their symptoms. Therefore, the investigation of agents that may deal with its more serious aspects is an important medical field for research. Numerous experimental studies have confirmed the important role of medicinal plants or their active components in the prevention and treatment, and in lowering risk factors of MS. As oxidative stress and inflammation are involved in the association between obesity, insulin resistance (IR) and hypertension, antioxidant and anti-inflammatory plant components like polyphenols might be useful as a treatment for MS. The aqueous extract of Hibiscus Sabdariffa L (HSE), rich in several polyphenols, is commonly and effectively used in native medicines against hypertension, diabetes and liver disorders. HSE has also shown therapeutic promise in the prevention of MS in patients, probably due to its polyphenol content. Curcumins, derived from the spice turmeric, and resveratrol, polyphenols found in grapes and red wine respectively, in addition to their antioxidant and anti-inflammatory properties, inhibit preadipocyte proliferation, de novo lipogenesis and fat accumulation in liver. Thus, due to their efficacy in the regulation of multiple targets, polyphenols have received considerable interest as potential therapeutic agents for the prevention and treatment of MS. This review discusses the therapeutic use of HSE, as well as curcumin and resveratrol, in the context of obesity as an initiator of insulin resistance and hypertension, the two main features of MS, together with the underlying mechanisms of action.
代谢综合征（MS）是一组与肥胖相关的病症，其中每种病症都会增加心血管疾病风险。对于患有MS的患者而言，遵循能够改善其症状的饮食/运动方案并非易事。因此，研究可能应对其更严重方面的药物是一个重要的医学研究领域。大量实验研究已证实药用植物或其活性成分在MS的预防、治疗及降低风险因素方面发挥着重要作用。由于氧化应激和炎症与肥胖、胰岛素抵抗（IR）及高血压之间存在关联，像多酚这类具有抗氧化和抗炎作用的植物成分可能对MS具有治疗作用。富含多种多酚的玫瑰茄水提取物（HSE），在传统医学中常用于治疗高血压、糖尿病和肝脏疾病，且效果显著。HSE在预防MS患者方面也显示出治疗前景，这可能归因于其多酚含量。姜黄素源自香料姜黄，白藜芦醇分别存在于葡萄和红酒中，它们除了具有抗氧化和抗炎特性外，还能抑制前脂肪细胞增殖、从头脂肪生成及肝脏脂肪堆积。因此，由于多酚在调节多个靶点方面的功效，它们作为预防和治疗MS的潜在治疗剂受到了广泛关注。本综述在肥胖作为胰岛素抵抗和高血压（MS的两个主要特征）的引发因素的背景下，探讨了HSE以及姜黄素和白藜芦醇的治疗用途，同时阐述了其潜在的作用机制。
