Instituto de Biología Molecular y Celular (IBMC), Universidad Miguel Hernández (UMH), Edificio Torregaitán, Elche 03202, Spain.
Department of Analytical Chemistry, University of Granada, Avda. Fuentenueva s/n, Granada 18071, Spain.
Nutrients. 2017 Aug 20;9(8):907. doi: 10.3390/nu9080907.
Improper diet can alter gene expression by breaking the energy balance equation and changing metabolic and oxidative stress biomarkers, which can result in the development of obesity-related metabolic disorders. The pleiotropic effects of dietary plant polyphenols are capable of counteracting by modulating different key molecular targets at the cell, as well as through epigenetic modifications. (HS)-derived polyphenols are known to ameliorate various obesity-related conditions. Recent evidence leads to propose the complex nature of the underlying mechanism of action. This multi-targeted mechanism includes the regulation of energy metabolism, oxidative stress and inflammatory pathways, transcription factors, hormones and peptides, digestive enzymes, as well as epigenetic modifications. This article reviews the accumulated evidence on the multiple anti-obesity effects of HS polyphenols in cell and animal models, as well as in humans, and its putative molecular targets. In silico studies reveal the capacity of several HS polyphenols to act as putative ligands for different digestive and metabolic enzymes, which may also deserve further attention. Therefore, a global approach including integrated and networked omics techniques, virtual screening and epigenetic analysis is necessary to fully understand the molecular mechanisms of HS polyphenols and metabolites involved, as well as their possible implications in the design of safe and effective polyphenolic formulations for obesity.
不当的饮食会打破能量平衡方程，并改变代谢和氧化应激生物标志物，从而导致与肥胖相关的代谢紊乱。膳食植物多酚的多效性作用能够通过调节细胞内不同的关键分子靶点，以及通过表观遗传修饰来对抗。（HS）衍生的多酚已被证明可以改善各种与肥胖相关的病症。最近的证据表明，作用机制具有复杂性。这种多靶点机制包括调节能量代谢、氧化应激和炎症途径、转录因子、激素和肽、消化酶以及表观遗传修饰。本文综述了 HS 多酚在细胞和动物模型以及人类中具有多种抗肥胖作用的累积证据，及其潜在的分子靶点。计算研究表明，几种 HS 多酚能够作为不同消化和代谢酶的潜在配体，这也值得进一步关注。因此，需要采用包括整合和联网组学技术、虚拟筛选和表观遗传分析在内的整体方法，以充分了解 HS 多酚及其代谢物所涉及的分子机制，以及它们在设计安全有效的肥胖症多酚制剂方面的可能意义。
