Department of Orthodontics, The University of Hong Kong, Hong Kong, China.
Int J Oral Sci. 2012 Jun;4(2):64-8. doi: 10.1038/ijos.2012.33.
Osteogenesis and angiogenesis are two closely correlated processes during bone growth, development, remodelling and repair.Vascular endothelial growth factor (VEGF) is an essential mediator during the process of angiogenesis. Based on an extensive literature search, which was carried out using the PubMed database and the keywords of osteogenesis, VEGF, endochondral ossification and intramembranous ossification, this manuscript reviews the role of VEGF in ossification, with emphasis on its effect in endochondral and intramembranous ossification. Osteogenesis and angiogenesis are closely correlated processes. VEGF acts as an essential mediator during these processes. It not only functions in bone angiogenesis but also in various aspects of bone development.
成骨作用和血管生成是骨生长、发育、重塑和修复过程中两个密切相关的过程。血管内皮生长因子（VEGF）是血管生成过程中的一个重要介质。本文通过广泛的文献检索，使用 PubMed 数据库和“成骨作用、VEGF、软骨内骨化和膜内骨化”的关键词，综述了 VEGF 在骨化中的作用，重点介绍了其在软骨内骨化和膜内骨化中的作用。成骨作用和血管生成是密切相关的过程。VEGF 作为一种重要的介质在这些过程中起作用。它不仅在骨血管生成中起作用，而且在骨发育的各个方面都起作用。
