一些市售罐装西班牙蘑菇的致突变性研究。

A study of the mutagenicity of some commercially canned Spanish mushrooms.

作者信息

Morales P, Bermúdez E, Sanz B, Hernández P E

机构信息

Departamento de Higiene y Tecnología de los Alimentos, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain.

出版信息

Food Chem Toxicol. 1990 Sep;28(9):607-11. doi: 10.1016/0278-6915(90)90167-l.

DOI:10.1016/0278-6915(90)90167-l

PMID:2272557

Abstract

The mutagenicity of two wild (Lactarius deliciosus and Boletus luteus) and two cultivated (Agaricus bisporus and Pleurotus ostreatus) mushrooms, preserved by canning and widely consumed in Spain, was studied in the Ames Salmonella/microsome test and in the CHO/HPRT assay system using mammalian cells. The mushroom extracts did not show mutagenicity in the microbial Ames test nor in the mammalian CHO-K1 cells, and this response was not modified by the presence of S-9 mix in the assay mixtures. Only the extracts from P. ostreatus showed a weak mutagenic activity in the CHO/HPRT assay in the presence of a metabolic activation system (S-9).

摘要

对两种野生蘑菇（美味乳菇和黄褐牛肝菌）以及两种栽培蘑菇（双孢蘑菇和平菇）进行了致突变性研究。这些蘑菇采用罐装保存，在西班牙广泛食用。研究采用了艾姆斯沙门氏菌/微粒体试验以及使用哺乳动物细胞的CHO/HPRT检测系统。蘑菇提取物在微生物艾姆斯试验和哺乳动物CHO-K1细胞中均未显示出致突变性，并且在检测混合物中加入S-9混合物后，这种反应也没有改变。只有平菇提取物在存在代谢激活系统（S-9）的情况下，在CHO/HPRT检测中显示出微弱的致突变活性。