Grotemeyer K H, Scharafinski H W, Schlake H P, Husstedt I W
Department of Neurology, University of Münster, FRG.
Headache. 1990 Oct;30(10):639-41. doi: 10.1111/j.1526-4610.1990.hed3010639.x.
In a double blind cross-over study, 28 patients, 5 male and 23 female, aged 31 +/- 14 years, after a run-in period of 8 weeks, were treated for 3 months with acetylsalicylic acid and for another 3 months with metoprolol, both in a prophylactic mode. Attack frequency was reduced significantly with both therapeutic regimens (ASA p less than 0.001, metoprolol p less than 0.00005). Reduction of attacks below 50% was seen with metoprolol in 14 cases, and with ASA in three cases. Even though ASA was of statistically significant efficacy in migraine prophylaxis, it clearly is not the drug of first choice in migraine prophylaxis.
在一项双盲交叉研究中，28名患者（5名男性和23名女性），年龄31±14岁，经过8周的导入期后，分别接受3个月的阿司匹林预防性治疗和另外3个月的美托洛尔预防性治疗。两种治疗方案均显著降低了发作频率（阿司匹林p<0.001，美托洛尔p<0.00005）。美托洛尔使发作次数减少50%以下的有14例，阿司匹林有3例。尽管阿司匹林在偏头痛预防方面有统计学显著疗效，但显然不是偏头痛预防的首选药物。
