Department of Medicine, Biochemistry and Nutrition Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Acupunct Med. 2012 Sep;30(3):208-13. doi: 10.1136/acupmed-2011-010121. Epub 2012 Jun 22.
Human leptin is a peptide hormone that is released from white adipocytes. The absence of leptin or its receptor leads to uncontrolled food intake, leading to obesity. In the present work, the effects of auricular acupressure combined with low-calorie diet on the leptin hormone level were investigated.
Volunteers (n=86) with body mass indices (BMI) between 25 and 45 kg/m² were randomised into a case (n=43) or a control (n=43) group. Participants in each group received a low-calorie diet for 6 weeks. The case group was treated with auricular acupressure and the control group received a sham procedure. Plasma leptin levels, body fat mass, body weight and BMI were measured before and after treatment.
Participants who received auricular acupressure showed significant reductions in their plasma leptin levels (18.57%, p<0.01) as well as in their body fat mass (4%, p<0.05). These changes were not observed in the control group. The reduction in leptin was significantly greater in the acupressure group than the controls.
Auricular acupressure combined with a low-calorie diet significantly reduced plasma levels of leptin. However, the mechanism of this reduction is not clear.
瘦素是一种由白色脂肪细胞分泌的肽类激素。瘦素或其受体的缺失会导致无法控制的进食，从而导致肥胖。本研究旨在探讨耳穴按压联合低热量饮食对瘦素水平的影响。
将体重指数（BMI）在 25 至 45 kg/m² 之间的志愿者（n=86）随机分为病例组（n=43）和对照组（n=43）。两组均接受为期 6 周的低热量饮食。病例组采用耳穴按压治疗，对照组给予假治疗。治疗前后测量血浆瘦素水平、体脂量、体重和 BMI。
接受耳穴按压的参与者血浆瘦素水平显著降低（18.57%，p<0.01），体脂量也降低了 4%（p<0.05）。对照组未观察到这些变化。与对照组相比，按压组的瘦素降低更为显著。
耳穴按压联合低热量饮食可显著降低血浆瘦素水平。然而，其降低的机制尚不清楚。
