INSERM U791, Faculté de Chirurgie Dentaire, Université de Nantes, 44042 Nantes, France.
Acta Biomater. 2012 Oct;8(10):3541-51. doi: 10.1016/j.actbio.2012.06.022. Epub 2012 Jun 21.
There is a growing interest in bone tissue engineering for bone repair after traumatic, surgical or pathological injury, such as osteolytic tumor or osteoporosis. In this regard, calcium phosphate (CaP) bone substitutes have been used extensively as bone-targeting drug-delivery systems. This localized approach improves the osteogenic potential of bone substitutes by delivering bone growth factors, thus extending their biofunctionality to any pathological context, including infection, irradiation, tumor and osteoporosis. This review briefly describes the physical and chemical processes implicated in the preparation of drug-delivering CaPs. It also describes the impact of these processes on the intrinsic properties of CaPs, especially in terms of the drug-release profile. In addition, this review focuses on the potential influence of drugs on the resorption rate of CaPs. Interestingly, by modulating the resorption parameters of CaP biomaterials, it should be possible to control the release of bone-stimulating ions, such as inorganic phosphate, in the vicinity of bone cells. Finally, recent in vitro and in vivo evaluations are extensively reported.
人们对骨组织工程越来越感兴趣，希望能在创伤、外科或病理性损伤（如溶骨性肿瘤或骨质疏松症）后修复骨骼。在这方面，钙磷酸盐（CaP）骨替代物已被广泛用作靶向骨的药物输送系统。这种局部方法通过输送骨生长因子来提高骨替代物的成骨潜能，从而将其生物功能扩展到任何病理环境，包括感染、辐射、肿瘤和骨质疏松症。本文简要描述了制备载药 CaP 所涉及的物理和化学过程。它还描述了这些过程对 CaP 固有特性的影响，特别是在药物释放特性方面。此外，本文重点介绍了药物对 CaP 吸收速率的潜在影响。有趣的是，通过调节 CaP 生物材料的吸收参数，应该可以控制骨刺激离子（如无机磷酸盐）在骨细胞附近的释放。最后，广泛报道了最近的体外和体内评估。
