AO Research Institute Davos, Clavadelerstrasse 8, Davos, Switzerland.
Acta Biomater. 2013 Mar;9(3):5421-30. doi: 10.1016/j.actbio.2012.11.022. Epub 2012 Nov 28.
The combination of hydrogels and calcium phosphate particles is emerging as a well-established trend for bone substitutes. Besides acting as binders for the inorganic phase, hydrogels within these hybrid materials can modulate cell colonization physically and biologically. The influence of hydrogels on the healing process can also be exploited through their capability to deliver drugs and cells for tissue engineering approaches. The aim of this review is to collect some recent progress in this field, with an emphasis on design aspects and possible future directions.
水凝胶和磷酸钙颗粒的组合正成为骨替代物的一种成熟趋势。除了充当无机相的粘合剂外，这些混合材料中的水凝胶还可以在物理和生物学上调节细胞定植。水凝胶还可以通过其输送药物和细胞用于组织工程方法的能力来利用其对愈合过程的影响。本综述的目的是收集该领域的一些最新进展，重点介绍设计方面和可能的未来方向。
