Orthopaedic Research Laboratory, Department of Orthopaedics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Injury. 2011 Sep;42 Suppl 2:S22-5. doi: 10.1016/j.injury.2011.06.008. Epub 2011 Jun 28.
Bone repair is a multi-dimensional process that requires osteogenic cells, an osteoconductive matrix, osteoinductive signalling, mechanical stability and vascularization. In clinical practice, bone substitute materials are being used for reconstructive purposes, bone stock augmentation, and bone repair. Over the last decade, the use of calcium phosphate (CaP) based bone substitute materials has increased exponentially. These bone substitute materials vary in composition, mechanical strength and biological mechanism of function, each having their own advantages and disadvantages. It is known that intrinsic material properties of CaP bone substitutes have a profound effect on their mechanical and biological behaviour and associated biodegradation. These material properties of bone substitutes, such as porosity, composition and geometry change the trade-off between mechanical and biological performance. The choice of the optimal bone substitutes is therefore not always an easy one, and largely depends on the clinical application and its associated biological and mechanical needs. Not all bone graft substitutes will perform the same way, and their performance in one clinical site may not necessarily predict their performance in another site. CaP bone substitutes unfortunately have yet to achieve optimal mechanical and biological performance and to date each material has its own trade-off between mechanical and biological performance. This review describes the effect of intrinsic material properties on biological performance, mechanical strength and biodegradability of CaP bone substitutes.
骨修复是一个多维的过程，需要成骨细胞、骨传导基质、骨诱导信号、机械稳定性和血管化。在临床实践中，骨替代材料被用于重建目的、增加骨量和修复骨。在过去的十年中，基于磷酸钙 (CaP) 的骨替代材料的使用呈指数级增长。这些骨替代材料在组成、机械强度和功能的生物学机制方面有所不同，每种材料都有其自身的优缺点。已知 CaP 骨替代材料的固有材料特性对其机械和生物学行为以及相关的生物降解有深远的影响。这些骨替代材料的特性，如孔隙率、组成和几何形状，改变了机械性能和生物性能之间的权衡。因此，选择最佳的骨替代材料并不总是一件容易的事，在很大程度上取决于临床应用及其相关的生物学和机械需求。并非所有的骨移植替代物都能以同样的方式发挥作用，它们在一个临床部位的表现不一定能预测其在另一个部位的表现。不幸的是，CaP 骨替代材料尚未达到最佳的机械和生物学性能，迄今为止，每种材料在机械性能和生物学性能之间都存在权衡。本综述描述了内在材料特性对 CaP 骨替代材料的生物学性能、机械强度和生物降解性的影响。
