在体人脑中谷胱甘肽（GSH）的双重选择性多量子化学位移成像和 T(1)弛豫时间测量。
Doubly selective multiple quantum chemical shift imaging and T(1) relaxation time measurement of glutathione (GSH) in the human brain in vivo.
机构信息
Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS 66160, USA.
出版信息
NMR Biomed. 2013 Jan;26(1):28-34. doi: 10.1002/nbm.2815. Epub 2012 Jun 22.
Abstract
Mapping of a major antioxidant, glutathione (GSH), was achieved in the human brain in vivo using a doubly-selective multiple quantum filtering based chemical shift imaging (CSI) of GSH at 3 T. Both in vivo and phantom tests in CSI and single voxel measurements were consistent with excellent suppression of overlapping signals from creatine, γ-Amino butyric acid (GABA) and macromolecules. GSH concentration in the fronto-parietal region was 1.20 ± 0.16 µmol/g (mean ± SD, n = 7). The longitudinal relaxation time (T(1) ) of GSH in the human brain was 397 ± 44 ms (mean ± SD, n = 5), which was substantially shorter than that of other metabolites. This GSH-CSI method permits us to address regional differences of GSH in the human brain under conditions where oxidative stress has been implicated, including multiple sclerosis, aging and neurodegenerative diseases.
摘要
采用基于双选择性多量子滤波的化学位移成像（CSI）技术，在 3T 场强下对人体内的主要抗氧化剂谷胱甘肽（GSH）进行了定位研究。CSI 中的体内和仿体测试以及单体素测量均表明，该方法可极好地抑制来自肌酸、γ-氨基丁酸（GABA）和大分子的重叠信号。额顶叶区域的 GSH 浓度为 1.20 ± 0.16 µmol/g（均值 ± 标准差，n = 7）。人脑 GSH 的纵向弛豫时间（T1）为 397 ± 44 ms（均值 ± 标准差，n = 5），明显短于其他代谢物。这种 GSH-CSI 方法可使我们在涉及氧化应激的情况下，包括多发性硬化症、衰老和神经退行性疾病，研究人脑内 GSH 的区域差异。
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