Levakov Aleksandra, Vucković Nada, Dolai Matilda, Kaćanski Mihaela Mocko, Bozanić Snezana
Center for Pathology and Histology, Clinical Center of Vojvodina, Novi Sad.
Med Pregl. 2012 May-Jun;65(5-6):191-5.
Age-related skin changes can be induced by chronological ageing, manifested in subcutaneous fat reduction, and photo-ageing eliciting increased elastotic substance in the upper dermis, destruction of its fibrilar structure, augmented intercellular substance and moderate inflammatory infiltrate. Forty-five biopsy skin samples of the sun-exposed and sun-protected skin were analyzed. The patients were both males and females, aged from 17 to 81 years. The thickness of the epidermal layers and the number of cellular living layers is greater in younger skin. The amount of keratohyaline granules is enlarged in older skin. Dermoepidermal junction is flattened and the presence of elastotic material in the dermis is pronounced with age. The amount of inflammatory infiltrate is increased, the fibrous trabeculae are thickened in older skin and the atrophy of the hypodermis is observed. Chronological ageing alters the fibroblasts metabolism by reducing their life span, capacity to divide and produce collagen. During ageing, the enlargement of collagen fibrils diminishes the skin elasticity.
与年龄相关的皮肤变化可由自然衰老引起，表现为皮下脂肪减少，以及光老化导致真皮上层弹性物质增加、纤维结构破坏、细胞间物质增多和中等程度的炎症浸润。对45份暴露于阳光和受到防晒保护的皮肤活检样本进行了分析。患者包括男性和女性，年龄在17至81岁之间。较年轻皮肤的表皮层厚度和细胞活性层数量更大。老年皮肤中透明角质颗粒的数量增多。随着年龄增长，真皮表皮连接变平，真皮中弹性物质的存在更为明显。炎症浸润量增加，老年皮肤中的纤维小梁增厚，同时观察到皮下组织萎缩。自然衰老通过缩短成纤维细胞的寿命、分裂能力和产生胶原蛋白的能力来改变其新陈代谢。在衰老过程中，胶原纤维的增大会降低皮肤弹性。
