Department of Neurology, Neuropsychology Laboratory, Coimbra University Hospital, Coimbra, Portugal.
J Clin Exp Neuropsychol. 2012;34(8):841-52. doi: 10.1080/13803395.2012.689814. Epub 2012 Jun 25.
Serial position effects in word list learning have been used to differentiate normal aging and dementia. Prominent recency and diminished primacy have consistently been observed in Alzheimer's disease (AD). We examined serial position effects in patients with mild cognitive impairment (MCI), in patients with AD, and in normal healthy controls. Additionally, we classified MCI patients into those who progressed to AD (MCI-p) and those who did not (MCI-np). We compared two serial position measures: regional and standard scores. Regional scores, mainly the primacy effect, improved discrimination between MCI and controls and between MCI-np and MCI-p, proving to be more sensitive and specific than the recency effect.
词汇学习中的系列位置效应可用于区分正常衰老和痴呆。在阿尔茨海默病（AD）中，明显的近因效应和减弱的首因效应一直被观察到。我们研究了轻度认知障碍（MCI）患者、AD 患者和正常健康对照组的系列位置效应。此外，我们将 MCI 患者分为进展为 AD（MCI-p）和未进展为 AD（MCI-np）的患者。我们比较了两种系列位置测量方法：区域分数和标准分数。区域分数（主要是首因效应）提高了 MCI 与对照组、MCI-np 与 MCI-p 之间的区分度，证明比近因效应更敏感和特异。
