Layton Aging and Alzheimer's Disease Center, Oregon Health & Science University, Portland, OR 97239-3098, USA.
J Clin Exp Neuropsychol. 2011 Mar;33(3):292-9. doi: 10.1080/13803395.2010.516742. Epub 2010 Dec 2.
Mild cognitive impairment (MCI) is often associated with the preclinical phase of Alzheimer's disease (AD). Special scoring of word-list recall data for serial position has been suggested to improve discrimination of normal aging from dementia. We examined serial position effects in word-list recall for MCI participants compared to Alzheimer patients and controls. Individuals with MCI, like Alzheimer patients, had a diminished primacy effect in recalling words from a list. No alternative scoring system was better than standard scoring of word-list recall in distinguishing MCI patients from controls. Retention weighted scoring improved the discrimination of MCI and AD groups.
轻度认知障碍 (MCI) 通常与阿尔茨海默病 (AD) 的临床前阶段相关。有人提出对单词列表回忆数据进行特殊的序列位置评分，以提高正常衰老与痴呆的区分能力。我们研究了 MCI 参与者与阿尔茨海默病患者和对照组在单词列表回忆中的序列位置效应。与阿尔茨海默病患者一样，MCI 患者在回忆列表中的单词时，首要效应明显减弱。与标准的单词列表回忆评分相比，没有其他评分系统能更好地区分 MCI 患者和对照组。保留权重评分提高了 MCI 和 AD 组的区分能力。
