Yuen K Y, Seto W H, Choi C H, Ng W, Ho S W, Chau P Y
Department of Microbiology, University of Hong Kong.
J Infect. 1990 Nov;21(3):241-50. doi: 10.1016/0163-4453(90)93885-v.
The clinical findings relating to 11 patients in Hong Kong (HK) and to 43 patients described elsewhere, all with Streptococcus zooepidemicus septicaemia, are reviewed. There was a particular association with cardiovascular disease (27%) with seven cases of endocarditis, three of abdominal aortic aneurysm and two of deep venous thrombosis. Associations not previously reported included two cases of pharyngitis and two patients with persistent post-operative fever. The overall mortality was 22%. Both human and porcine strains of S. zooepidemicus from HK did not hydrolyse aesculin in contrast to the aesculin-positive biotypes reported previously. HK strains also had very mucoid colonies and capsules of hyaluronic acid were seen in electron micrographs. Samples of chromosomal DNA, extracted by means of HindIII restriction endonuclease, of strains from human beings and pigs were identical. The MIC of penicillin for all strains was less than or equal to 0.03 mg/l but the MBC for all was greater than 32 mg/l. Penicillin alone is generally sufficient for cure but combination with an aminoglycoside may be indicated in seriously ill patients. In our locality, pigs were incriminated as a possible source of human infection whereas consumption of contaminated dairy products is important elsewhere.
对香港11例及其他地方描述的43例人兽共患链球菌败血症患者的临床研究结果进行了回顾。该病与心血管疾病有特殊关联（27%），其中7例为心内膜炎，3例为腹主动脉瘤，2例为深静脉血栓形成。此前未报告的关联包括2例咽炎和2例术后持续发热患者。总死亡率为22%。与先前报告的七叶苷阳性生物型不同，香港的人源和猪源兽疫链球菌菌株均不水解七叶苷。香港菌株还具有非常粘稠的菌落，电子显微镜下可见透明质酸荚膜。通过HindIII限制性内切酶提取的人源和猪源菌株的染色体DNA样本是相同的。所有菌株对青霉素的最低抑菌浓度小于或等于0.03mg/L，但最低杀菌浓度均大于32mg/L。单独使用青霉素通常足以治愈，但对重症患者可能需要联合使用氨基糖苷类药物。在我们当地，猪被认为是人类感染的可能来源，而在其他地方，食用受污染的乳制品则很重要。
