Knospe W H, Husseini S G, Schwartz D
Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.
Int J Cell Cloning. 1990 Nov;8(6):425-30. doi: 10.1002/stem.5530080645.
Cellulose ester membranes (CEM) were enriched with the following purified matrix proteins: collagen I, II, IV, proteoglycan and laminin. Fifteen milligrams of each were placed on CEM which were then folded into open-ended tubes implanted i.p. and s.c. CEM were removed after 3, 6 and 12 months and examined histologically. There was no evidence of hematopoiesis or new bone formation on the implanted, enriched CEM at any of the intervals examined. Collagen I and proteoglycan-enriched CEM showed evidence of increased sinusoid-like vascular structures.
纤维素酯膜（CEM）富含以下纯化的基质蛋白：胶原蛋白I、II、IV、蛋白聚糖和层粘连蛋白。将每种15毫克置于CEM上，然后将其折叠成开口管，经腹腔内和皮下植入。在3、6和12个月后取出CEM并进行组织学检查。在任何检查的时间段内，植入的富含蛋白的CEM上均未发现造血或新骨形成的迹象。富含胶原蛋白I和蛋白聚糖的CEM显示出类窦状血管结构增加的迹象。
