Knospe W H, Husseini S G, Adler S S, Reddi A H
Exp Hematol. 1983 Nov;11(10):1021-6.
Mouse bone matrix powder was implanted subcutaneously or put into folded tubular cellulose ester membranes (CEM) and implanted i.p. Calcification and new bone formation did not develop. Sinusoidal vascularization of the matrix developed by 3 to 4 wk. Stromal cells such as fat cells and fibroblasts were present by 4 wk. Hematopoiesis was absent except for rare foci of granulopoiesis on some of the CEM at 6 wk. Rat bone matrix implanted subcutaneously into mice and mouse bone matrix implanted subcutaneously into rats failed to induce new bone formation or hematopoiesis.
将小鼠骨基质粉末皮下植入，或将其置于折叠的管状纤维素酯膜（CEM）中并腹腔内植入。未出现钙化和新骨形成。基质在3至4周时出现窦状血管化。4周时存在脂肪细胞和成纤维细胞等基质细胞。6周时，除了在一些CEM上有罕见的粒细胞生成灶外，未出现造血现象。将大鼠骨基质皮下植入小鼠以及将小鼠骨基质皮下植入大鼠均未能诱导新骨形成或造血。
