Orthopaedic Surgery, Albert Schweitzer hospital, Dordrecht, The Netherlands.
Int Orthop. 2012 Oct;36(10):2113-9. doi: 10.1007/s00264-012-1603-9. Epub 2012 Jun 26.
Platelet rich plasma (PRP) is derived from the patient's own blood. The activated blood platelets release a cocktail of growth factors, some of which are thought to initiate and stimulate repair. We compared two groups to investigate whether the use of PRP mixed with bone chips improves bone healing in patients with a skeletal defect.
In total, 41 patients were observed. One group underwent a high tibial osteotomy with the addition of PRP and bone chips in the open wedge. The other group underwent the same procedure without the addition of PRP. Six patients had to be excluded because of insufficient data or they were lost to follow-up. Bone healing was studied using computed tomography scanning. The blood was sequestered and PRP was produced using a blood cell separator with a PRP software program (Electa, Sorin Group, Mirandola, Italy).
Analysis focused on the remaining 35 patients. At baseline, there were no differences between the two groups for age, sex and side of operation. At one week postoperatively, the bone density under (p = 0.02) and above the wedge was significantly lower in the PRP group than the control group (p = 0.24). At six weeks postoperatively, no significant differences between the treatment groups were found. At 12 weeks, the PRP group had significantly lower bone density under the wedge compared to the control group (p = 0.01).
We found that patients with a skeletal defect did not benefit from the application of PRP mixed with an allograft regarding bone healing.
富血小板血浆 (PRP) 源自患者自身的血液。激活的血小板释放出生长因子的混合物，其中一些被认为可以启动和刺激修复。我们比较了两组患者，以调查 PRP 与骨屑混合使用是否可以改善有骨骼缺损的患者的骨愈合。
共观察了 41 名患者。一组患者在开放式楔形截骨术中加入 PRP 和骨屑进行高胫骨截骨术。另一组患者进行了相同的手术，但未加入 PRP。由于数据不足或失访，有 6 名患者被排除在外。使用计算机断层扫描研究骨愈合情况。使用血细胞分离机和 PRP 软件程序（意大利米兰多拉的 Sorin Group 的 Electa）采集血液并产生 PRP。
分析集中在其余 35 名患者。在基线时，两组在年龄、性别和手术侧方面没有差异。术后一周，PRP 组骨密度在楔形物下（p = 0.02）和楔形物上均显著低于对照组（p = 0.24）。术后 6 周，两组之间没有发现显著差异。术后 12 周，PRP 组在楔形物下的骨密度明显低于对照组（p = 0.01）。
我们发现，有骨骼缺损的患者在应用 PRP 与同种异体骨混合治疗时，并未从骨愈合中获益。
