富血小板血浆对大骨软骨缺损愈合的再生作用。
The regenerative effect of platelet-rich plasma on healing in large osteochondral defects.
机构信息
Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.
出版信息
Int Orthop. 2010 Apr;34(4):589-97. doi: 10.1007/s00264-009-0793-2. Epub 2009 May 12.
Abstract
Platelet-rich plasma (PRP), a platelet concentrate made of autogenous blood, has been used to improve bone and soft tissue defect healing in recent years. The aim of this study was to assess the effect of PRP on articular cartilage defects in a rabbit model. Forty-eight osteochondral defects created in the femoropatellar groove were (a) left untreated, (b) treated with autogenous PRP in a poly-lactic-glycolic acid (PLGA), or (c) with PLGA alone. Platelets were enriched 5.12-fold compared to normal blood in the PRP. After four and 12 weeks, the explanted tissue specimens were assessed by macroscopic examination, micro-computed tomography, and histological evaluation. Macroscopic examination, micro-computed tomography and histology of the newly formed cartilage and bone in the defect differ significantly between the PRP-treated and the untreated groups, and stimulatory effect of PRP on osteochondral formation was observed. In conclusion, PRP in PLGA improves osteochondral healing in a rabbit model.
摘要
富血小板血浆（PRP）是一种由自体血液制成的血小板浓缩物，近年来已被用于改善骨和软组织缺损的愈合。本研究旨在评估 PRP 在兔模型中对关节软骨缺损的作用。在髌股凹槽中创建了 48 个骨软骨缺损，（a）未治疗，（b）用聚乳酸-乙醇酸（PLGA）中的自体 PRP 治疗，或（c）仅用 PLGA 治疗。PRP 中的血小板比正常血液富集了 5.12 倍。在 4 周和 12 周后，通过大体检查、微计算机断层扫描和组织学评估来评估取出的组织标本。PRP 治疗组与未治疗组之间，在缺陷处新形成的软骨和骨的宏观检查、微计算机断层扫描和组织学有明显差异，并且观察到 PRP 对骨软骨形成的刺激作用。总之，PLGA 中的 PRP 可改善兔模型中的骨软骨愈合。
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