Suhaeb Abdulrazzaq Mahmod, Naveen Sangeetha, Mansor Azura, Kamarul Tunku
Tissue Engineering Group (TEG), National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL), Department of Orthopaedic Surgery, Faculty of Medicine, University of Malaya, 50603 Lembah Pantai, Kuala Lumpur, Malaysia.
Indian J Exp Biol. 2012 Jun;50(6):383-90.
Despite being a complex degenerative joint disease, studies on osteoarthritis (OA) suggest that its progression can be reduced by the use of hyaluronic acid (HA) or mesenchymal stem cells (MSC). The present study thus aims to examine the effects of MSC, HA and the combination of HA-MSC in treating OA in rat model. The histological observations using O'Driscoll score indicate that it is the use of HA and MSC independently and not their combination that delays the progression of OA. In conclusion, the preliminary study suggest that the use of either HA or MSCs effectively reduces OA progression better than their combined use.
尽管骨关节炎（OA）是一种复杂的退行性关节疾病，但对其研究表明，使用透明质酸（HA）或间充质干细胞（MSC）可减缓其进展。因此，本研究旨在考察MSC、HA以及HA-MSC组合对大鼠骨关节炎模型的治疗效果。使用奥德里斯科尔评分法进行的组织学观察表明，是单独使用HA和MSC而非它们的组合延缓了骨关节炎的进展。总之，初步研究表明，单独使用HA或MSC比联合使用能更有效地减缓骨关节炎的进展。
